The C terminus of p73 is essential for hippocampal development

Cite This

Files in this item

Checksum: MD5:5a7a0bd62833be2c37e8f6bcb54a9d28

AMELIO, Ivano, Emanuele PANATTA, Maria Victoria NIKLISON-CHIROU, Joern R. STEINERT, Massimiliano AGOSTINI, Nobuhiro MORONE, Richard A. KNIGHT, Gerry MELINO, 2020. The C terminus of p73 is essential for hippocampal development. In: Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. 117(27), pp. 15694-15701. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.2000917117

@article{Amelio2020termi-57061, title={The C terminus of p73 is essential for hippocampal development}, year={2020}, doi={10.1073/pnas.2000917117}, number={27}, volume={117}, issn={0027-8424}, journal={Proceedings of the National Academy of Sciences of the United States of America}, pages={15694--15701}, author={Amelio, Ivano and Panatta, Emanuele and Niklison-Chirou, Maria Victoria and Steinert, Joern R. and Agostini, Massimiliano and Morone, Nobuhiro and Knight, Richard A. and Melino, Gerry} }

Morone, Nobuhiro Panatta, Emanuele Melino, Gerry Steinert, Joern R. Agostini, Massimiliano Panatta, Emanuele Steinert, Joern R. The p53 family member p73 has a complex gene structure, including alternative promoters and alternative splicing of the 3' UTR. This results in a complex range of isoforms whose biological relevance largely remains to be determined. By deleting exon 13 (which encodes a sterile α motif) from the Trp73 gene, we selectively engineered mice to replace the most abundantly expressed C-terminal isoform, p73α, with a shorter product of alternative splicing, p73β. These mice (Trp73 <sup>Δ13/Δ13</sup> ) display severe neurodevelopmental defects with significant functional and morphological abnormalities. Replacement of p73α with p73β results in the depletion of Cajal-Retzius (CR) cells in embryonic stages, thus depriving the developing hippocampus of the pool of neurons necessary for correct hippocampal architecture. Consequently, Trp73<sup> Δ13/Δ13</sup> mice display severe hippocampal dysgenesis, reduced synaptic functionality and impaired learning and memory capabilities. Our data shed light on the relevance of p73 alternative splicing and show that the full-length C terminus of p73 is essential for hippocampal development. eng Amelio, Ivano The C terminus of p73 is essential for hippocampal development Melino, Gerry 2022-03-30T07:33:07Z Morone, Nobuhiro Amelio, Ivano 2022-03-30T07:33:07Z 2020 Niklison-Chirou, Maria Victoria Niklison-Chirou, Maria Victoria Agostini, Massimiliano Attribution 4.0 International Knight, Richard A. Knight, Richard A.

Downloads since Mar 30, 2022 (Information about access statistics)

Amelio_2-ztoefq7n8eq23.pdf 13

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account