Liquid biopsies and cancer omics

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AMELIO, Ivano, Riccardo BERTOLO, Pierluigi BOVE, Oreste Claudio BUONOMO, Eleonora CANDI, Marcello CHIOCCHI, Chiara CIPRIANI, Nicola DI DANIELE, Carlo GANINI, Gerry MELINO, 2020. Liquid biopsies and cancer omics. In: Cell Death Discovery. Nature Publishing Group. 6(1), 131. eISSN 2058-7716. Available under: doi: 10.1038/s41420-020-00373-0

@article{Amelio2020-11-26Liqui-57058, title={Liquid biopsies and cancer omics}, year={2020}, doi={10.1038/s41420-020-00373-0}, number={1}, volume={6}, journal={Cell Death Discovery}, author={Amelio, Ivano and Bertolo, Riccardo and Bove, Pierluigi and Buonomo, Oreste Claudio and Candi, Eleonora and Chiocchi, Marcello and Cipriani, Chiara and Di Daniele, Nicola and Ganini, Carlo and Melino, Gerry}, note={Article Number: 131} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:issued>2020-11-26</dcterms:issued> <dc:creator>Melino, Gerry</dc:creator> <dc:creator>Ganini, Carlo</dc:creator> <dc:contributor>Bove, Pierluigi</dc:contributor> <dcterms:abstract xml:lang="eng">The development of the sequencing technologies allowed the generation of huge amounts of molecular data from a single cancer specimen, allowing the clinical oncology to enter the era of the precision medicine. This massive amount of data is highlighting new details on cancer pathogenesis but still relies on tissue biopsies, which are unable to capture the dynamic nature of cancer through its evolution. This assumption led to the exploration of non-tissue sources of tumoral material opening the field of liquid biopsies. Blood, together with body fluids such as urines, or stool, from cancer patients, are analyzed applying the techniques used for the generation of omics data. With blood, this approach would allow to take into account tumor heterogeneity (since the circulating components such as CTCs, ctDNA, or ECVs derive from each cancer clone) in a time dependent manner, resulting in a somehow "real-time" understanding of cancer evolution. Liquid biopsies are beginning nowdays to be applied in many cancer contexts and are at the basis of many clinical trials in oncology.</dcterms:abstract> <dc:contributor>Ganini, Carlo</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dc:contributor>Chiocchi, Marcello</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Di Daniele, Nicola</dc:contributor> <dc:creator>Buonomo, Oreste Claudio</dc:creator> <dc:creator>Chiocchi, Marcello</dc:creator> <dc:date rdf:datatype="">2022-03-30T07:06:17Z</dc:date> <dc:contributor>Buonomo, Oreste Claudio</dc:contributor> <dc:contributor>Candi, Eleonora</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Cipriani, Chiara</dc:creator> <dcterms:rights rdf:resource=""/> <dc:creator>Di Daniele, Nicola</dc:creator> <dc:creator>Bertolo, Riccardo</dc:creator> <bibo:uri rdf:resource=""/> <dc:language>eng</dc:language> <dc:creator>Candi, Eleonora</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dc:rights>Attribution 4.0 International</dc:rights> <dc:creator>Bove, Pierluigi</dc:creator> <dc:contributor>Bertolo, Riccardo</dc:contributor> <dcterms:available rdf:datatype="">2022-03-30T07:06:17Z</dcterms:available> <dcterms:title>Liquid biopsies and cancer omics</dcterms:title> <dc:contributor>Amelio, Ivano</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Cipriani, Chiara</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Melino, Gerry</dc:contributor> </rdf:Description> </rdf:RDF>

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