KOPS - The Institutional Repository of the University of Konstanz

Clinical update on head and neck cancer : molecular biology and ongoing challenges

Clinical update on head and neck cancer : molecular biology and ongoing challenges

Cite This

Files in this item

Checksum: MD5:d5cc61176659f60dd6e91736ae6e3c56

ALSAHAFI, Elham, Katheryn BEGG, Ivano AMELIO, Nina RAULF, Philippe LUCARELLI, Thomas SAUTER, Mahvash TAVASSOLI, 2019. Clinical update on head and neck cancer : molecular biology and ongoing challenges. In: Cell Death & Disease. Nature Publishing Group. 10(8), 540. eISSN 2041-4889. Available under: doi: 10.1038/s41419-019-1769-9

@article{Alsahafi2019Clini-56995, title={Clinical update on head and neck cancer : molecular biology and ongoing challenges}, year={2019}, doi={10.1038/s41419-019-1769-9}, number={8}, volume={10}, journal={Cell Death & Disease}, author={Alsahafi, Elham and Begg, Katheryn and Amelio, Ivano and Raulf, Nina and Lucarelli, Philippe and Sauter, Thomas and Tavassoli, Mahvash}, note={Article Number: 540} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56995"> <dc:creator>Begg, Katheryn</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:issued>2019</dcterms:issued> <dc:creator>Sauter, Thomas</dc:creator> <dcterms:title>Clinical update on head and neck cancer : molecular biology and ongoing challenges</dcterms:title> <dc:contributor>Sauter, Thomas</dc:contributor> <dc:creator>Lucarelli, Philippe</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dc:contributor>Amelio, Ivano</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56995/3/Alsahafi_2-1n8z9qgb975wa4.pdf"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56995"/> <dc:creator>Raulf, Nina</dc:creator> <dc:contributor>Alsahafi, Elham</dc:contributor> <dc:creator>Alsahafi, Elham</dc:creator> <dcterms:abstract xml:lang="eng">Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies, surgery and radiotherapy represent the primary treatment options for most patients. But these treatments are associated with significant morbidity and a reduction in quality of life. Resistance to both radiotherapy and the only available targeted therapy, and subsequent relapse are common. Research has therefore focussed on identifying biomarkers to stratify patients into clinically meaningful groups and to develop more effective targeted therapies. However, as we are now discovering, the poor response to therapy and aggressive nature of HNSCCs is not only affected by the complex alterations in intracellular signalling pathways but is also heavily influenced by the behaviour of the extracellular microenvironment. The HNSCC tumour landscape is an environment permissive of these tumours' aggressive nature, fostered by the actions of the immune system, the response to tumour hypoxia and the influence of the microbiome. Solving these challenges now rests on expanding our knowledge of these areas, in parallel with a greater understanding of the molecular biology of HNSCC subtypes. This update aims to build on our earlier 2014 review by bringing up to date our understanding of the molecular biology of HNSCCs and provide insights into areas of ongoing research and perspectives for the future.</dcterms:abstract> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:creator>Tavassoli, Mahvash</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56995/3/Alsahafi_2-1n8z9qgb975wa4.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-25T08:26:43Z</dcterms:available> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Lucarelli, Philippe</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-25T08:26:43Z</dc:date> <dc:contributor>Tavassoli, Mahvash</dc:contributor> <dc:contributor>Raulf, Nina</dc:contributor> <dc:contributor>Begg, Katheryn</dc:contributor> <dc:rights>Attribution 4.0 International</dc:rights> </rdf:Description> </rdf:RDF>

Downloads since Mar 25, 2022 (Information about access statistics)

Alsahafi_2-1n8z9qgb975wa4.pdf 31

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


My Account