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Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes

Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes

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MADINDA, Nadège F., Bernhard EHLERS, Joel O. WERTHEIM, Chantal AKOUA-KOFFI, Richard A. BERGL, Christophe BOESCH, Dieudonné Boji Mungu AKONKWA, Barbara FRUTH, Sébastien CALVIGNAC-SPENCER, 2016. Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes. In: Journal of virology. American Society for Microbiology (ASM). 90(19), pp. 8531-8541. ISSN 0022-538X. eISSN 1098-5514. Available under: doi: 10.1128/JVI.00247-16

@article{Madinda2016Asses-56967, title={Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes}, year={2016}, doi={10.1128/JVI.00247-16}, number={19}, volume={90}, issn={0022-538X}, journal={Journal of virology}, pages={8531--8541}, author={Madinda, Nadège F. and Ehlers, Bernhard and Wertheim, Joel O. and Akoua-Koffi, Chantal and Bergl, Richard A. and Boesch, Christophe and Akonkwa, Dieudonné Boji Mungu and Fruth, Barbara and Calvignac-Spencer, Sébastien} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56967"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-23T15:49:33Z</dcterms:available> <dc:contributor>Ehlers, Bernhard</dc:contributor> <dc:creator>Calvignac-Spencer, Sébastien</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56967"/> <dc:contributor>Wertheim, Joel O.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Bergl, Richard A.</dc:creator> <dc:contributor>Madinda, Nadège F.</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Wertheim, Joel O.</dc:creator> <dc:creator>Ehlers, Bernhard</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Madinda, Nadège F.</dc:creator> <dc:contributor>Bergl, Richard A.</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Akoua-Koffi, Chantal</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Boesch, Christophe</dc:contributor> <dc:contributor>Calvignac-Spencer, Sébastien</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dcterms:issued>2016</dcterms:issued> <dc:contributor>Akonkwa, Dieudonné Boji Mungu</dc:contributor> <dcterms:abstract xml:lang="eng">It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV. We reassess this question by focusing on a single lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus (MCPyV) lineage. By characterizing the genetic diversity of these viruses in seven African great ape taxa, we show that they exhibit very strong host specificity. Reconciliation analyses identify more codivergence than noncodivergence events. In addition, we find that a number of host and PyV divergence events are synchronous. Collectively, our results support codivergence as the dominant process at play during the evolution of the MCPyV lineage. More generally, our results add to the growing body of evidence suggesting an ancient and stable association of PyV and their animal hosts.</dcterms:abstract> <dc:creator>Fruth, Barbara</dc:creator> <dc:creator>Boesch, Christophe</dc:creator> <dc:creator>Akoua-Koffi, Chantal</dc:creator> <dc:contributor>Fruth, Barbara</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Akonkwa, Dieudonné Boji Mungu</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-23T15:49:33Z</dc:date> <dcterms:title>Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes</dcterms:title> </rdf:Description> </rdf:RDF>

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