The hypoxic tumour microenvironment

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PETROVA, Varvara, Margherita ANNICCHIARICO-PETRUZZELLI, Gerry MELINO, Ivano AMELIO, 2018. The hypoxic tumour microenvironment. In: Oncogenesis. Nature Publishing Group. 7, 10. eISSN 2157-9024. Available under: doi: 10.1038/s41389-017-0011-9

@article{Petrova2018-01-24hypox-56926, title={The hypoxic tumour microenvironment}, year={2018}, doi={10.1038/s41389-017-0011-9}, volume={7}, journal={Oncogenesis}, author={Petrova, Varvara and Annicchiarico-Petruzzelli, Margherita and Melino, Gerry and Amelio, Ivano}, note={Article Number: 10} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:creator>Petrova, Varvara</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dc:contributor>Petrova, Varvara</dc:contributor> <dcterms:abstract xml:lang="eng">Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxia-inducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.</dcterms:abstract> <dcterms:rights rdf:resource=""/> <dc:creator>Melino, Gerry</dc:creator> <dc:contributor>Annicchiarico-Petruzzelli, Margherita</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dcterms:issued>2018-01-24</dcterms:issued> <dcterms:title>The hypoxic tumour microenvironment</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:rights>Attribution 4.0 International</dc:rights> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:language>eng</dc:language> <dc:creator>Annicchiarico-Petruzzelli, Margherita</dc:creator> <dcterms:available rdf:datatype="">2022-03-21T12:58:55Z</dcterms:available> <dc:date rdf:datatype="">2022-03-21T12:58:55Z</dc:date> </rdf:Description> </rdf:RDF>

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