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Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2

Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2

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WERTHEIM, Joel O., Reilly HOSTAGER, Diane RYU, Kevin MERKEL, Samuel ANGEDAKIN, Mimi ARANDJELOVIC, Emmanuel Ayuk AYIMISIN, Fred BABWETEERA, Barbara FRUTH, Sébastien CALVIGNAC-SPENCER, 2021. Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2. In: Molecular biology and evolution. Oxford University Press. 38(7), pp. 2818-2830. ISSN 0737-4038. eISSN 1537-1719. Available under: doi: 10.1093/molbev/msab072

@article{Wertheim2021Disco-56908, title={Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2}, year={2021}, doi={10.1093/molbev/msab072}, number={7}, volume={38}, issn={0737-4038}, journal={Molecular biology and evolution}, pages={2818--2830}, author={Wertheim, Joel O. and Hostager, Reilly and Ryu, Diane and Merkel, Kevin and Angedakin, Samuel and Arandjelovic, Mimi and Ayimisin, Emmanuel Ayuk and Babweteera, Fred and Fruth, Barbara and Calvignac-Spencer, Sébastien} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56908"> <dc:creator>Calvignac-Spencer, Sébastien</dc:creator> <dc:contributor>Hostager, Reilly</dc:contributor> <dc:contributor>Ayimisin, Emmanuel Ayuk</dc:contributor> <dc:creator>Fruth, Barbara</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56908"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc/4.0/"/> <dc:contributor>Angedakin, Samuel</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-17T11:29:14Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-17T11:29:14Z</dc:date> <dc:rights>Attribution-NonCommercial 4.0 International</dc:rights> <dc:creator>Ayimisin, Emmanuel Ayuk</dc:creator> <dcterms:issued>2021</dcterms:issued> <dc:creator>Ryu, Diane</dc:creator> <dc:creator>Wertheim, Joel O.</dc:creator> <dcterms:abstract xml:lang="eng">Viruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and cross-species transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experienced multiple cross-species transmission events over the past 3 My, the most recent of which occurred between humans and bonobos around 1 Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens.</dcterms:abstract> <dc:contributor>Fruth, Barbara</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Ryu, Diane</dc:contributor> <dc:creator>Merkel, Kevin</dc:creator> <dc:creator>Arandjelovic, Mimi</dc:creator> <dc:contributor>Babweteera, Fred</dc:contributor> <dc:contributor>Wertheim, Joel O.</dc:contributor> <dc:contributor>Calvignac-Spencer, Sébastien</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56908/1/Wertheim_2-1qt86tjrxjy1d2.pdf"/> <dc:creator>Hostager, Reilly</dc:creator> <dc:creator>Angedakin, Samuel</dc:creator> <dc:contributor>Arandjelovic, Mimi</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56908/1/Wertheim_2-1qt86tjrxjy1d2.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2</dcterms:title> <dc:creator>Babweteera, Fred</dc:creator> <dc:contributor>Merkel, Kevin</dc:contributor> </rdf:Description> </rdf:RDF>

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