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Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair

Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair

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DI GIOVANNI, Emilia, Silvia BUONVINO, Ivano AMELIO, Sonia MELINO, 2020. Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair. In: International Journal of Molecular Sciences. MDPI. 21(5), 1638. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms21051638

@article{DiGiovanni2020-02-28Gluta-56831, title={Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair}, year={2020}, doi={10.3390/ijms21051638}, number={5}, volume={21}, issn={1661-6596}, journal={International Journal of Molecular Sciences}, author={Di Giovanni, Emilia and Buonvino, Silvia and Amelio, Ivano and Melino, Sonia}, note={Article Number: 1638} }

Amelio, Ivano Buonvino, Silvia eng Di Giovanni, Emilia Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair 2022-03-11T10:17:52Z Melino, Sonia The endogenous gasotransmitter H<sub>2</sub>S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H<sub>2</sub>S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for cardiovascular and neurodegenerative diseases. Nonetheless, the effects of H<sub>2</sub>S-releasing agents on the growth of stem cells have not been fully investigated. H<sub>2</sub>S preconditioning can enhance mesenchymal stem cell survival after post-ischaemic myocardial implantation; therefore, stem cell therapy combined with H<sub>2</sub>S may be relevant in cell-based therapy for regenerative medicine. Here, we studied the effects of slow-releasing H<sub>2</sub>S agents on the cell growth and differentiation of cardiac Lin<sup>-</sup> Sca1<sup>+</sup> human mesenchymal stem cells (cMSC) and on normal human dermal fibroblasts (NHDF). In particular, we investigated the effects of water-soluble GSH-garlic conjugates (GSGa) on cMSC compared to other H<sub>2</sub>S-releasing agents, such as Na<sub>2</sub>S and GYY4137. GSGa treatment of cMSC and NHDF increased their cell proliferation and migration in a concentration dependent manner with respect to the control. GSGa treatment promoted an upregulation of the expression of proteins involved in oxidative stress protection, cell-cell adhesion and commitment to differentiation. These results highlight the effects of H<sub>2</sub>S-natural donors as biochemical factors that promote MSC homing, increasing their safety profile and efficacy after transplantation, and the value of these donors in developing functional 3D-stem cell delivery systems for cardiac muscle tissue repair and regeneration. Buonvino, Silvia Di Giovanni, Emilia Amelio, Ivano 2022-03-11T10:17:52Z Attribution 4.0 International 2020-02-28 Melino, Sonia

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