Serological determinants of COVID-19

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NOCE, Annalisa, Maria Luisa SANTORO, Giulia MARRONE, Cartesio D'AGOSTINI, Ivano AMELIO, Andrea DUGGENTO, Manfredi TESAURO, Nicola DI DANIELE, 2020. Serological determinants of COVID-19. In: Biology direct. BioMed Central. 15(1), 21. eISSN 1745-6150. Available under: doi: 10.1186/s13062-020-00276-1

@article{Noce2020Serol-56676, title={Serological determinants of COVID-19}, year={2020}, doi={10.1186/s13062-020-00276-1}, number={1}, volume={15}, journal={Biology direct}, author={Noce, Annalisa and Santoro, Maria Luisa and Marrone, Giulia and D'Agostini, Cartesio and Amelio, Ivano and Duggento, Andrea and Tesauro, Manfredi and Di Daniele, Nicola}, note={Article Number: 21} }

Background<br />Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spreaded rapidly worldwide, as far as it has become a global pandemic. Therefore, the introduction of serological tests for determination of IgM and IgG antibodies has become the main diagnostic tool, useful for tracking the spread of the virus and for consequently allowing its containment. In our study we compared point of care test (POCT) lateral flow immunoassay (FIA) vs automated chemiluminescent immunoassay (CLIA), in order to assess their specificity and sensibility for COVID-19 antibodies detection.<br />Results<br />We find that different specificities and sensitivities for IgM and IgG tests. Notably IgM POCT FIA method vs CLIA method (gold standard) has a low sensitivity (0.526), while IgG POCT FIA method vs CLIA method (gold standard) test has a much higher sensitivity (0.937); further, with respect of IgG, FIA and CLIA could arguably provide equivalent information. Conclusions<br />FIA method could be helpful in assessing in short time, the possible contagiousness of subjects that for work reasons cannot guarantee “social distancing”. Serological determinants of COVID-19 2022-02-24T11:37:52Z Attribution 4.0 International 2022-02-24T11:37:52Z Santoro, Maria Luisa 2020 Di Daniele, Nicola D'Agostini, Cartesio Amelio, Ivano Noce, Annalisa Duggento, Andrea Tesauro, Manfredi Santoro, Maria Luisa Noce, Annalisa Marrone, Giulia Amelio, Ivano Marrone, Giulia D'Agostini, Cartesio Duggento, Andrea Tesauro, Manfredi Di Daniele, Nicola eng

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