Integrin-β4 is a novel transcriptional target of TAp73

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

XIE, Ningxia, Polina VIKHREVA, Margherita ANNICCHIARICO-PETRUZZELLI, Ivano AMELIO, Nicolai BARLEV, Richard A. KNIGHT, Gerry MELINO, 2018. Integrin-β4 is a novel transcriptional target of TAp73. In: Cell Cycle. Taylor & Francis. 17(5), pp. 589-594. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.1080/15384101.2017.1403684

@article{Xie2018Integ-56665, title={Integrin-β4 is a novel transcriptional target of TAp73}, year={2018}, doi={10.1080/15384101.2017.1403684}, number={5}, volume={17}, issn={1538-4101}, journal={Cell Cycle}, pages={589--594}, author={Xie, Ningxia and Vikhreva, Polina and Annicchiarico-Petruzzelli, Margherita and Amelio, Ivano and Barlev, Nicolai and Knight, Richard A. and Melino, Gerry} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Xie, Ningxia</dc:creator> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Knight, Richard A.</dc:contributor> <dcterms:abstract xml:lang="eng">As a member of p53 family, p73 has attracted intense investigations due to its structural and functional similarities to p53. Among more than ten p73 variants, the transactivation (TA) domain-containing isoform TAp73 is the one that imitates the p53's behavior most. TAp73 induces apoptosis and cell cycle arrest, which endows it the capacity of tumour suppression. Also, it can exert diverse biological influences on cells through activating a complex and context dependent transcriptional programme. The transcriptional activities further broaden its roles in more intricate biological processes. In this article, we report that p73 is a positive regulator of a cell adhesion related gene named integrin β4 (ITGB4). This finding may have implications for the dissection of the biological mechanisms underlining p73 functions.</dcterms:abstract> <bibo:uri rdf:resource=""/> <dc:date rdf:datatype="">2022-02-23T13:00:15Z</dc:date> <dc:creator>Barlev, Nicolai</dc:creator> <dc:contributor>Barlev, Nicolai</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="">2022-02-23T13:00:15Z</dcterms:available> <dc:contributor>Xie, Ningxia</dc:contributor> <dc:contributor>Annicchiarico-Petruzzelli, Margherita</dc:contributor> <dc:creator>Annicchiarico-Petruzzelli, Margherita</dc:creator> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Amelio, Ivano</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Vikhreva, Polina</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:creator>Melino, Gerry</dc:creator> <dcterms:rights rdf:resource=""/> <dc:creator>Amelio, Ivano</dc:creator> <dc:creator>Knight, Richard A.</dc:creator> <dc:contributor>Vikhreva, Polina</dc:contributor> <dcterms:issued>2018</dcterms:issued> <dcterms:title>Integrin-β4 is a novel transcriptional target of TAp73</dcterms:title> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


My Account