KOPS - The Institutional Repository of the University of Konstanz

Cell death pathologies : targeting death pathways and the immune system for cancer therapy

Cell death pathologies : targeting death pathways and the immune system for cancer therapy

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

PENTIMALLI, Francesca, Sandro GRELLI, Nicola DI DANIELE, Gerry MELINO, Ivano AMELIO, 2019. Cell death pathologies : targeting death pathways and the immune system for cancer therapy. In: Genes and Immunity. Springer Nature. 20(7), pp. 539-554. ISSN 1466-4879. eISSN 1476-5470. Available under: doi: 10.1038/s41435-018-0052-x

@article{Pentimalli2019death-56663, title={Cell death pathologies : targeting death pathways and the immune system for cancer therapy}, year={2019}, doi={10.1038/s41435-018-0052-x}, number={7}, volume={20}, issn={1466-4879}, journal={Genes and Immunity}, pages={539--554}, author={Pentimalli, Francesca and Grelli, Sandro and Di Daniele, Nicola and Melino, Gerry and Amelio, Ivano} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56663"> <dcterms:issued>2019</dcterms:issued> <dc:contributor>Di Daniele, Nicola</dc:contributor> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Pentimalli, Francesca</dc:contributor> <dc:creator>Pentimalli, Francesca</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-23T12:46:20Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Di Daniele, Nicola</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>Cell death pathologies : targeting death pathways and the immune system for cancer therapy</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-23T12:46:20Z</dc:date> <dc:creator>Grelli, Sandro</dc:creator> <dc:contributor>Amelio, Ivano</dc:contributor> <dcterms:abstract xml:lang="eng">Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically been exclusively associated with classical apoptosis; however, increasing evidence indicates that several alternative mechanisms orchestrate multiple death pathways, such as ferroptosis, entosis, necroptosis and immunogenic cell death, each with distinct underlying molecular mechanisms. Although pharmacological targeting of cell death pathways has been the subject of intensive efforts in recent decades with a dominant focus on targeting apoptosis, the identification of these novel death pathways has opened additional venues for intervention in cancer cells and the immune system. In this mini-review, we cover some recent progress on major recently emerged cell death modalities, emphasizing their potential clinical and therapeutic implications. We also discuss the interplay between cell death and immune response, highlighting the potential of the combination of traditional anticancer therapy and immunocheckpoint blockade. While attempting to stimulate discussion and draw attention to the possible clinical impact of these more recently emerged cell death modalities, we also cover the major progress achieved in translating strategies for manipulation of apoptotic pathways into the clinic, focusing on the attempts to target the anti-apoptotic protein BCL2 and the tumour suppressor p53.</dcterms:abstract> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Melino, Gerry</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Grelli, Sandro</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56663"/> <dc:rights>terms-of-use</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


My Account