Regulation of Adult Neurogenesis in Mammalian Brain

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NIKLISON-CHIROU, Maria Victoria, Massimiliano AGOSTINI, Ivano AMELIO, Gerry MELINO, 2020. Regulation of Adult Neurogenesis in Mammalian Brain. In: International journal of molecular sciences. Molecular Diversity Preservation International (MDPI). 21(14), 4869. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms21144869

@article{NiklisonChirou2020-07-09Regul-56641, title={Regulation of Adult Neurogenesis in Mammalian Brain}, year={2020}, doi={10.3390/ijms21144869}, number={14}, volume={21}, issn={1661-6596}, journal={International journal of molecular sciences}, author={Niklison-Chirou, Maria Victoria and Agostini, Massimiliano and Amelio, Ivano and Melino, Gerry}, note={Article Number: 4869} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56641"> <dc:rights>Attribution 4.0 International</dc:rights> <dc:language>eng</dc:language> <dcterms:issued>2020-07-09</dcterms:issued> <dc:contributor>Melino, Gerry</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-22T11:47:00Z</dcterms:available> <dc:contributor>Agostini, Massimiliano</dc:contributor> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:creator>Melino, Gerry</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56641"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-22T11:47:00Z</dc:date> <dcterms:title>Regulation of Adult Neurogenesis in Mammalian Brain</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:creator>Amelio, Ivano</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56641/3/Amelio_2-iz2ujugshxrp2.pdf"/> <dc:creator>Agostini, Massimiliano</dc:creator> <dcterms:abstract xml:lang="eng">Adult neurogenesis is a multistage process by which neurons are generated and integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. Neurogenesis plays a fundamental role in postnatal brain, where it is required for neuronal plasticity. Moreover, perturbation of adult neurogenesis contributes to several human diseases, including cognitive impairment and neurodegenerative diseases. The interplay between extrinsic and intrinsic factors is fundamental in regulating neurogenesis. Over the past decades, several studies on intrinsic pathways, including transcription factors, have highlighted their fundamental role in regulating every stage of neurogenesis. However, it is likely that transcriptional regulation is part of a more sophisticated regulatory network, which includes epigenetic modifications, non-coding RNAs and metabolic pathways. Here, we review recent findings that advance our knowledge in epigenetic, transcriptional and metabolic regulation of adult neurogenesis in the SGZ of the hippocampus, with a special attention to the p53-family of transcription factors.</dcterms:abstract> <dc:contributor>Niklison-Chirou, Maria Victoria</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56641/3/Amelio_2-iz2ujugshxrp2.pdf"/> <dc:creator>Niklison-Chirou, Maria Victoria</dc:creator> </rdf:Description> </rdf:RDF>

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