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Oxytocin modulates neural circuitry for social cognition and fear in humans

Oxytocin modulates neural circuitry for social cognition and fear in humans

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KIRSCH, Peter, Christine ESSLINGER, Qiang CHEN, Daniela MIER, Stefanie LIS, Sarina SIDDHANTI, Harald GRUPPE, Venkata S. MATTAY, Bernd GALLHOFER, Andreas MEYER-LINDENBERG, 2005. Oxytocin modulates neural circuitry for social cognition and fear in humans. In: The Journal of Neuroscience. Society for Neuroscience. 25(49), pp. 11489-11493. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.3984-05.2005

@article{Kirsch2005-12-07Oxyto-56601, title={Oxytocin modulates neural circuitry for social cognition and fear in humans}, year={2005}, doi={10.1523/JNEUROSCI.3984-05.2005}, number={49}, volume={25}, issn={0270-6474}, journal={The Journal of Neuroscience}, pages={11489--11493}, author={Kirsch, Peter and Esslinger, Christine and Chen, Qiang and Mier, Daniela and Lis, Stefanie and Siddhanti, Sarina and Gruppe, Harald and Mattay, Venkata S. and Gallhofer, Bernd and Meyer-Lindenberg, Andreas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56601"> <dc:contributor>Lis, Stefanie</dc:contributor> <dc:contributor>Gruppe, Harald</dc:contributor> <dc:creator>Lis, Stefanie</dc:creator> <dc:contributor>Esslinger, Christine</dc:contributor> <dc:contributor>Kirsch, Peter</dc:contributor> <dc:creator>Mier, Daniela</dc:creator> <dc:creator>Gruppe, Harald</dc:creator> <dc:creator>Mattay, Venkata S.</dc:creator> <dc:creator>Kirsch, Peter</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56601/1/Kirsch_2-hus9n0fdf21h8.pdf"/> <dc:rights>terms-of-use</dc:rights> <dc:language>eng</dc:language> <dc:contributor>Mier, Daniela</dc:contributor> <dc:creator>Chen, Qiang</dc:creator> <dcterms:abstract xml:lang="eng">In non-human mammals, the neuropeptide oxytocin is a key mediator of complex emotional and social behaviors, including attachment, social recognition, and aggression. Oxytocin reduces anxiety and impacts on fear conditioning and extinction. Recently, oxytocin administration in humans was shown to increase trust, suggesting involvement of the amygdala, a central component of the neurocircuitry of fear and social cognition that has been linked to trust and highly expresses oxytocin receptors in many mammals. However, no human data on the effects of this peptide on brain function were available. Here, we show that human amygdala function is strongly modulated by oxytocin. We used functional magnetic resonance imaging to image amygdala activation by fear-inducing visual stimuli in 15 healthy males after double-blind crossover intranasal application of placebo or oxytocin. Compared with placebo, oxytocin potently reduced activation of the amygdala and reduced coupling of the amygdala to brainstem regions implicated in autonomic and behavioral manifestations of fear. Our results indicate a neural mechanism for the effects of oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.</dcterms:abstract> <dc:creator>Meyer-Lindenberg, Andreas</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:creator>Siddhanti, Sarina</dc:creator> <dc:creator>Esslinger, Christine</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-18T14:47:04Z</dc:date> <dc:contributor>Mattay, Venkata S.</dc:contributor> <dcterms:issued>2005-12-07</dcterms:issued> <dc:creator>Gallhofer, Bernd</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Siddhanti, Sarina</dc:contributor> <dc:contributor>Gallhofer, Bernd</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Chen, Qiang</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56601/1/Kirsch_2-hus9n0fdf21h8.pdf"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:title>Oxytocin modulates neural circuitry for social cognition and fear in humans</dcterms:title> <dc:contributor>Meyer-Lindenberg, Andreas</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-18T14:47:04Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56601"/> </rdf:Description> </rdf:RDF>

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