KOPS - The Institutional Repository of the University of Konstanz

Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia

Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia

Cite This

Files in this item

Checksum: MD5:c53b81311e3c1e37278df54eff51bca9

MAURIELLO, Alessandro, Manuel SCIMECA, Ivano AMELIO, Renato MASSOUD, Antonio NOVELLI, Francesca DI LORENZO, Susanna FINOCCHIARO, Carolina CIMINO, Giuseppe NOVELLI, Gerry MELINO, 2021. Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia. In: Cell death & disease. Nature Publishing Group. 12(8), 762. eISSN 2041-4889. Available under: doi: 10.1038/s41419-021-04058-z

@article{Mauriello2021Throm-56539, title={Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia}, year={2021}, doi={10.1038/s41419-021-04058-z}, number={8}, volume={12}, journal={Cell death & disease}, author={Mauriello, Alessandro and Scimeca, Manuel and Amelio, Ivano and Massoud, Renato and Novelli, Antonio and Di Lorenzo, Francesca and Finocchiaro, Susanna and Cimino, Carolina and Novelli, Giuseppe and Melino, Gerry}, note={Article Number: 762} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56539"> <dc:contributor>Novelli, Antonio</dc:contributor> <dc:creator>Novelli, Giuseppe</dc:creator> <dc:creator>Novelli, Antonio</dc:creator> <dc:contributor>Di Lorenzo, Francesca</dc:contributor> <dc:contributor>Massoud, Renato</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56539/3/Amelio_2-qwc8z2qxaf9f3.pdf"/> <dc:contributor>Novelli, Giuseppe</dc:contributor> <dc:creator>Amelio, Ivano</dc:creator> <dc:contributor>Finocchiaro, Susanna</dc:contributor> <dc:creator>Finocchiaro, Susanna</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:contributor>Melino, Gerry</dc:contributor> <dc:creator>Scimeca, Manuel</dc:creator> <dcterms:issued>2021</dcterms:issued> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56539"/> <dc:creator>Cimino, Carolina</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Mauriello, Alessandro</dc:contributor> <dc:rights>Attribution 4.0 International</dc:rights> <dc:creator>Mauriello, Alessandro</dc:creator> <dcterms:abstract xml:lang="eng">While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia.</dcterms:abstract> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56539/3/Amelio_2-qwc8z2qxaf9f3.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Melino, Gerry</dc:creator> <dc:contributor>Cimino, Carolina</dc:contributor> <dc:contributor>Scimeca, Manuel</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-14T11:00:06Z</dc:date> <dc:creator>Massoud, Renato</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-14T11:00:06Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Di Lorenzo, Francesca</dc:creator> <dc:contributor>Amelio, Ivano</dc:contributor> <dcterms:title>Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia</dcterms:title> </rdf:Description> </rdf:RDF>

Downloads since Feb 14, 2022 (Information about access statistics)

Amelio_2-qwc8z2qxaf9f3.pdf 45

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account