Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-ezke7bw0u0bi4 |
Author: | Panatta, Emanuele; Zampieri, Carlotta; Melino, Gerry; Amelio, Ivano |
Year of publication: | 2021 |
Published in: | Biology Direct ; 16 (2021). - 14. - BioMed Central. - eISSN 1745-6150 |
Pubmed ID: | 34362419 |
DOI (citable link): | https://dx.doi.org/10.1186/s13062-021-00298-3 |
Summary: |
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the recent years additional p53-mediated tumour suppression mechanisms have been described, questioning the contribution of its canonical pathway for tumour suppression. These include regulation of alternative cell death modalities (i.e. ferroptosis), cell metabolism and the emerging role in RNA stability. Here we briefly summarize our knowledge on p53 "canonical DNA damage response" and discuss the most relevant recent findings describing potential mechanistic explanation of p53-mediated tumour suppression.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Tumour suppression, DNA damage, Stress response, Cell death |
Link to License: | Attribution 4.0 International |
Refereed: | Yes |
PANATTA, Emanuele, Carlotta ZAMPIERI, Gerry MELINO, Ivano AMELIO, 2021. Understanding p53 tumour suppressor network. In: Biology Direct. BioMed Central. 16, 14. eISSN 1745-6150. Available under: doi: 10.1186/s13062-021-00298-3
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