@article{Carecho2022Circu-56361,
  year={2022},
  doi={10.1002/mnfr.202100959},
  title={Circulating (Poly)phenol Metabolites : Neuroprotection in a 3D Cell Model of Parkinson's Disease},
  number={21},
  volume={66},
  issn={1613-4125},
  journal={Molecular Nutrition and Food Research},
  author={Carecho, Rafael and Figueira, Inês and Terrasso, Ana Paula and Godinho-Pereira, Joana and de Oliveira Sequeira, Catarina and Pereira, Sofia Azeredo and Milenkovic, Dragan and Leist, Marcel and Brito, Catarina and Nunes Dos Santos, Cláudia},
  note={Article Number: 2100959}
}

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    <dc:creator>Godinho-Pereira, Joana</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Milenkovic, Dragan</dc:contributor>
    <dc:contributor>Nunes Dos Santos, Cláudia</dc:contributor>
    <dc:creator>Milenkovic, Dragan</dc:creator>
    <dc:contributor>Terrasso, Ana Paula</dc:contributor>
    <dc:creator>Pereira, Sofia Azeredo</dc:creator>
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    <dcterms:title>Circulating (Poly)phenol Metabolites : Neuroprotection in a 3D Cell Model of Parkinson's Disease</dcterms:title>
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    <dc:contributor>Pereira, Sofia Azeredo</dc:contributor>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:contributor>Godinho-Pereira, Joana</dc:contributor>
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    <dc:creator>Nunes Dos Santos, Cláudia</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-26T10:11:43Z</dc:date>
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    <dc:contributor>de Oliveira Sequeira, Catarina</dc:contributor>
    <dc:rights>Attribution 4.0 International</dc:rights>
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    <dc:contributor>Figueira, Inês</dc:contributor>
    <dc:creator>de Oliveira Sequeira, Catarina</dc:creator>
    <dc:contributor>Carecho, Rafael</dc:contributor>
    <dcterms:issued>2022</dcterms:issued>
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    <dc:creator>Leist, Marcel</dc:creator>
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    <dcterms:abstract xml:lang="eng">Scope&lt;br /&gt;Diets rich in (poly)phenols have been associated with positive effects on neurodegenerative disorders, such as Parkinson's disease (PD). Several low-molecular weight (poly)phenol metabolites (LMWPM) are found in the plasma after consumption of (poly)phenol-rich food. It is expected that LMWPM, upon reaching the brain, may have beneficial effects against both oxidative stress and neuroinflammation, and possibly attenuate cell death mechanisms relate to the loss of dopaminergic neurons in PD.&lt;br /&gt;&lt;br /&gt;Methods and Results&lt;br /&gt;This study investigates the neuroprotective potential of two blood-brain barrier permeant LMWPM, catechol-O-sulfate (cat-sulf), and pyrogallol-O-sulfate (pyr-sulf), in a human 3D cell model of PD. Neurospheroids were generated from LUHMES neuronal precursor cells and challenged by 1-methyl-4-phenylpyridinium (MPP&lt;sup&gt;+&lt;/sup&gt;) to induce neuronal stress. LMWPM pretreatments were differently neuroprotective towards MPP&lt;sup&gt;+&lt;/sup&gt; insult, presenting distinct effects on the neuronal transcriptome. Particularly, cat-sulf pretreatment appeared to boost counter-regulatory defense mechanisms (preconditioning). When MPP&lt;sup&gt;+&lt;/sup&gt; is applied, both LMWPM positively modulated glutathione metabolism and heat-shock response, as also favorably shifting the balance of pro/anti-apoptotic proteins.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;Our findings point to the potential of LMWPM to trigger molecular mechanisms that help dopaminergic neurons to cope with a subsequent toxic insult. They are promising molecules to be further explored in the context of preventing and attenuating parkinsonian neurodegeneration.</dcterms:abstract>
    <dc:creator>Figueira, Inês</dc:creator>
    <dc:creator>Terrasso, Ana Paula</dc:creator>
    <dc:creator>Brito, Catarina</dc:creator>
    <dc:creator>Carecho, Rafael</dc:creator>
    <dc:contributor>Brito, Catarina</dc:contributor>
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