KOPS - The Institutional Repository of the University of Konstanz

Stingray Venom Proteins : Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach

Stingray Venom Proteins : Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach

Cite This

Files in this item

Checksum: MD5:eca02a88fb31058419598f86c91839a0

KIRCHHOFF, Kim N., André BILLION, Christian R. VOOLSTRA, Stephan KREMB, Thomas WILKE, Andreas VILCINSKAS, 2022. Stingray Venom Proteins : Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach. In: Marine Drugs. MDPI. 20(1), 27. eISSN 1660-3397. Available under: doi: 10.3390/md20010027

@article{Kirchhoff2022-01Sting-56077, title={Stingray Venom Proteins : Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach}, year={2022}, doi={10.3390/md20010027}, number={1}, volume={20}, journal={Marine Drugs}, author={Kirchhoff, Kim N. and Billion, André and Voolstra, Christian R. and Kremb, Stephan and Wilke, Thomas and Vilcinskas, Andreas}, note={Article Number: 27} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56077"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-05T08:27:59Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>Attribution 4.0 International</dc:rights> <dc:contributor>Kirchhoff, Kim N.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56077"/> <dc:contributor>Wilke, Thomas</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:language>eng</dc:language> <dc:contributor>Voolstra, Christian R.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-05T08:27:59Z</dcterms:available> <dc:contributor>Billion, André</dc:contributor> <dc:contributor>Kremb, Stephan</dc:contributor> <dc:contributor>Vilcinskas, Andreas</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2022-01</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>Stingray Venom Proteins : Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56077/1/Kirchhoff_2-bp20nxz8qpk71.pdf"/> <dc:creator>Billion, André</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56077/1/Kirchhoff_2-bp20nxz8qpk71.pdf"/> <dc:creator>Kremb, Stephan</dc:creator> <dc:creator>Wilke, Thomas</dc:creator> <dc:creator>Kirchhoff, Kim N.</dc:creator> <dc:creator>Voolstra, Christian R.</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dcterms:abstract xml:lang="eng">Animal venoms offer a valuable source of potent new drug leads, but their mechanisms of action are largely unknown. We therefore developed a novel network pharmacology approach based on multi-omics functional data integration to predict how stingray venom disrupts the physiological systems of target animals. We integrated 10 million transcripts from five stingray venom transcriptomes and 848,640 records from three high-content venom bioactivity datasets into a large functional data network. The network featured 216 signaling pathways, 29 of which were shared and targeted by 70 transcripts and 70 bioactivity hits. The network revealed clusters for single envenomation outcomes, such as pain, cardiotoxicity and hemorrhage. We carried out a detailed analysis of the pain cluster representing a primary envenomation symptom, revealing bibrotoxin and cholecystotoxin-like transcripts encoding pain-inducing candidate proteins in stingray venom. The cluster also suggested that such pain-inducing toxins primarily activate the inositol-3-phosphate receptor cascade, inducing intracellular calcium release. We also found strong evidence for synergistic activity among these candidates, with nerve growth factors cooperating with the most abundant translationally-controlled tumor proteins to activate pain signaling pathways. Our network pharmacology approach, here applied to stingray venom, can be used as a template for drug discovery in neglected venomous species.</dcterms:abstract> <dc:creator>Vilcinskas, Andreas</dc:creator> </rdf:Description> </rdf:RDF>

Downloads since Jan 5, 2022 (Information about access statistics)

Kirchhoff_2-bp20nxz8qpk71.pdf 92

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account