KOPS - The Institutional Repository of the University of Konstanz

Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level

Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level

Cite This

Files in this item

Checksum: MD5:6774f38a6815fcee18cec1f2509b94e5

ZAMOSCIK, Vera, Stephanie N. L. SCHMIDT, Rafael BRAVO, Lierni UGARTEMENDIA, Thomas PLIEGER, Ana B. RODRÍGUEZ, Martin REUTER, Peter KIRSCH, 2021. Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level. In: Scientific Reports. Springer Nature. 11(1), 21637. eISSN 2045-2322. Available under: doi: 10.1038/s41598-021-01164-y

@article{Zamoscik2021-11-04Trypt-55835, title={Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level}, year={2021}, doi={10.1038/s41598-021-01164-y}, number={1}, volume={11}, journal={Scientific Reports}, author={Zamoscik, Vera and Schmidt, Stephanie N. L. and Bravo, Rafael and Ugartemendia, Lierni and Plieger, Thomas and Rodríguez, Ana B. and Reuter, Martin and Kirsch, Peter}, note={Article Number: 21637} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/55835"> <dc:contributor>Zamoscik, Vera</dc:contributor> <dc:creator>Bravo, Rafael</dc:creator> <dc:creator>Reuter, Martin</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-12-10T08:44:35Z</dc:date> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Rodríguez, Ana B.</dc:creator> <dc:contributor>Rodríguez, Ana B.</dc:contributor> <dc:rights>Attribution 4.0 International</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55835/1/Zamoscik_2-dns1mhxb0wu62.pdf"/> <dc:contributor>Bravo, Rafael</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:language>eng</dc:language> <dc:creator>Ugartemendia, Lierni</dc:creator> <dc:contributor>Reuter, Martin</dc:contributor> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:contributor>Schmidt, Stephanie N. L.</dc:contributor> <dcterms:issued>2021-11-04</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Zamoscik, Vera</dc:creator> <dc:contributor>Ugartemendia, Lierni</dc:contributor> <dcterms:abstract xml:lang="eng">Understanding of emotions and intentions are key processes in social cognition at which serotonin is an important neuromodulator. Its precursor is the essential amino acid tryptophan (TRP). Reduced TRP availability leads to weaker impulse control ability and higher aggression, while TRP supplementation promotes confidence. In a double-blind placebo-controlled fMRI study with 77 healthy adults, we investigated the influence of a 4 week TRP enriched diet and an acute 5-hydroxytryptophan (5-HTP) intake on two social-cognitive tasks, a moral evaluation and an emotion recognition task. With 5-HTP, immoral behavior without negative consequences was rated as more reprehensible. Additionally, during story reading, activation in insula and supramarginal gyrus was increased after TRP intake. No significant effects of TRP on emotion recognition were identified for the whole sample. Importantly, emotion recognition ability decreased with age which was for positive emotions compensated by TRP. Since the supramarginal gyrus is associated with empathy, pain and related information integration results could be interpreted as reflecting stricter evaluation of negative behavior due to better integration of information. Improved recognition of positive emotions with TRP in older participants supports the use of a TRP-rich diet to compensate for age related decline in social-cognitive processes.</dcterms:abstract> <dc:creator>Plieger, Thomas</dc:creator> <dc:contributor>Plieger, Thomas</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55835/1/Zamoscik_2-dns1mhxb0wu62.pdf"/> <dc:creator>Kirsch, Peter</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/55835"/> <dc:contributor>Kirsch, Peter</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-12-10T08:44:35Z</dcterms:available> <dc:creator>Schmidt, Stephanie N. L.</dc:creator> <dcterms:title>Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level</dcterms:title> </rdf:Description> </rdf:RDF>

Downloads since Dec 10, 2021 (Information about access statistics)

Zamoscik_2-dns1mhxb0wu62.pdf 56

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account