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Association between fat-soluble vitamins and self-reported health status : a cross-sectional analysis of the MARK-AGE cohort

Association between fat-soluble vitamins and self-reported health status : a cross-sectional analysis of the MARK-AGE cohort

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STOKES, Caroline S., Daniela WEBER, Stefan WAGENPFEIL, Wolfgang STUETZ, Maria MORENO-VILLANUEVA, Martijn E. T. DOLLÉ, Eugène JANSEN, Efstathios S. GONOS, Jürgen BERNHARDT, Alexander BÜRKLE, 2022. Association between fat-soluble vitamins and self-reported health status : a cross-sectional analysis of the MARK-AGE cohort. In: British Journal of Nutrition (BJN). Cambridge University Press. 128(3), pp. 433-443. ISSN 0007-1145. eISSN 1475-2662. Available under: doi: 10.1017/S0007114521004633

@article{Stokes2022-08-14Assoc-55662, title={Association between fat-soluble vitamins and self-reported health status : a cross-sectional analysis of the MARK-AGE cohort}, year={2022}, doi={10.1017/S0007114521004633}, number={3}, volume={128}, issn={0007-1145}, journal={British Journal of Nutrition (BJN)}, pages={433--443}, author={Stokes, Caroline S. and Weber, Daniela and Wagenpfeil, Stefan and Stuetz, Wolfgang and Moreno-Villanueva, Maria and Dollé, Martijn E. T. and Jansen, Eugène and Gonos, Efstathios S. and Bernhardt, Jürgen and Bürkle, Alexander} }

Self-rated health (SRH) is associated with higher risk of death. Since low plasma levels of fat-soluble vitamins are related to mortality, we aimed to assess whether plasma concentrations of vitamins A, D and E were associated with SRH in the MARK-AGE study. We included 3158 participants (52% female) aged between 35-75 years. Cross-sectional data were collected via questionnaires. An enzyme immunoassay quantified 25-hydroxyvitamin D and HPLC determined α-tocopherol and retinol plasma concentrations. The median 25-hydroxyvitamin D and retinol concentrations differed significantly (P<0.001) between SRH categories, and were lower in the combined fair/poor category versus the excellent, very good, good categories (25-hydroxvitamin D: 40.8 vs. 51.9, 49.3, 46.7 nmol/l, respectively; retinol: 1.67 vs. 1.75, 1.74, 1.70 µmol/l, respectively). Both vitamin D and retinol status were independently associated with fair/poor SRH in multiple regression analyses: adjusted ORs (95% CI) for the vitamin D insufficiency, deficiency, severe deficiency categories were 1.33 (1.06-1.68), 1.50 (1.17-1.93), and 1.83 (1.34-2.50) respectively; P=0.015, P=0.001, P<0.001, and for the second/third/fourth retinol quartiles: 1.44 (1.18-1.75), 1.57 (1.28-1.93), 1.49 (1.20-1.84); all P<0.001. No significant associations were reported for α-tocopherol quartiles. Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of these modifiable nutrients on health status are warranted. Moreno-Villanueva, Maria Gonos, Efstathios S. Wagenpfeil, Stefan Bürkle, Alexander Jansen, Eugène Stuetz, Wolfgang Wagenpfeil, Stefan Stuetz, Wolfgang Stokes, Caroline S. Association between fat-soluble vitamins and self-reported health status : a cross-sectional analysis of the MARK-AGE cohort Bernhardt, Jürgen Bernhardt, Jürgen Weber, Daniela Moreno-Villanueva, Maria terms-of-use 2021-11-25T14:19:24Z Bürkle, Alexander 2022-08-14 2021-11-25T14:19:24Z Dollé, Martijn E. T. Weber, Daniela Dollé, Martijn E. T. Jansen, Eugène eng Gonos, Efstathios S. Stokes, Caroline S.

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