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Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease : protocol of a one-year prospective follow-up study

Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease : protocol of a one-year prospective follow-up study

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SRULIJES, Karin, David J. MACK, Jochen KLENK, Lars SCHWICKERT, Espen A. F. IHLEN, Michael SCHWENK, Ulrich LINDEMANN, Miriam MEYER, K. C. SRIJANA, Markus A. HOBERT, 2015. Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease : protocol of a one-year prospective follow-up study. In: BMC neurology. BioMed Central. 15, 192. eISSN 1471-2377. Available under: doi: 10.1186/s12883-015-0447-5

@article{Srulijes2015-10-09Assoc-55640, title={Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease : protocol of a one-year prospective follow-up study}, year={2015}, doi={10.1186/s12883-015-0447-5}, volume={15}, journal={BMC neurology}, author={Srulijes, Karin and Mack, David J. and Klenk, Jochen and Schwickert, Lars and Ihlen, Espen A. F. and Schwenk, Michael and Lindemann, Ulrich and Meyer, Miriam and Srijana, K. C. and Hobert, Markus A.}, note={Article Number: 192} }

Klenk, Jochen Schwickert, Lars Mack, David J. Meyer, Miriam terms-of-use 2021-11-24T11:52:50Z Schwenk, Michael Hobert, Markus A. Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease : protocol of a one-year prospective follow-up study 2021-11-24T11:52:50Z Srijana, K. C. eng Schwenk, Michael Ihlen, Espen A. F. Lindemann, Ulrich Srijana, K. C. Meyer, Miriam Schwickert, Lars Srulijes, Karin Klenk, Jochen Hobert, Markus A. Lindemann, Ulrich Srulijes, Karin Ihlen, Espen A. F. 2015-10-09 Background:<br />Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investigated. This paper provides an overview of current approaches to simultaneously measure eye and body movements, particularly for analyzing the association of vestibulo-ocular reflex (VOR) suppression, postural deficits and falls in neurogeriatric risk cohorts. Moreover, VOR suppression is measured during head-fixed target presentation and during gaze shifting while postural control is challenged. Using these approaches, we aim at identifying quantitative parameters of eye-head-coordination during postural balance and gait, as indicators of fall risk.<br /><br />Methods/Design:<br />Patients with Progressive Supranuclear Palsy (PSP) or Parkinson’s disease (PD), age- and sex-matched healthy older adults, and a cohort of young healthy adults will be recruited. Baseline assessment will include a detailed clinical assessment, covering medical history, neurological examination, disease specific clinical rating scales, falls-related self-efficacy, activities of daily living, neuro-psychological screening, assessment of mobility function and a questionnaire for retrospective falls. Moreover, participants will simultaneously perform eye and head movements (fixating a head-fixed target vs. shifting gaze to light emitting diodes in order to quantify vestibulo-ocular reflex suppression ability) under different conditions (sitting, standing, or walking). An eye/head tracker synchronized with a 3-D motion analysis system will be used to quantify parameters related to eye-head-coordination, postural balance, and gait. Established outcome parameters related to VOR suppression ability (e.g., gain, saccadic reaction time, frequency of saccades) and motor related fall risk (e.g., step-time variability, postural sway) will be calculated. Falls will be assessed prospectively over 12 months via protocols and monthly telephone interviews.<br /><br />Discussion:<br />This study protocol describes an experimental setup allowing the analysis of simultaneously assessed eye, head and body movements. Results will improve our understanding of the influence of the interplay between eye, head and body movements on falls in geriatric high-risk cohorts. Mack, David J.

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