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High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

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MARCON, Luciano, Xavier DIEGO, James SHARPE, Patrick MÜLLER, 2016. High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals. In: eLife. eLife Sciences Publications. 5, e14022. eISSN 2050-084X. Available under: doi: 10.7554/eLife.14022

@article{Marcon2016Hight-55590, title={High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals}, year={2016}, doi={10.7554/eLife.14022}, volume={5}, journal={eLife}, author={Marcon, Luciano and Diego, Xavier and Sharpe, James and Müller, Patrick}, note={Article Number: e14022} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/55590"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55590/3/Marcon_2-8pxa9z8gm0it8.pdf"/> <dc:contributor>Müller, Patrick</dc:contributor> <dcterms:issued>2016</dcterms:issued> <dc:contributor>Marcon, Luciano</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals</dcterms:title> <dc:contributor>Sharpe, James</dc:contributor> <dcterms:abstract xml:lang="eng">The Turing reaction-diffusion model explains how identical cells can self-organize to form spatial patterns. It has been suggested that extracellular signaling molecules with different diffusion coefficients underlie this model, but the contribution of cell-autonomous signaling components is largely unknown. We developed an automated mathematical analysis to derive a catalog of realistic Turing networks. This analysis reveals that in the presence of cell-autonomous factors, networks can form a pattern with equally diffusing signals and even for any combination of diffusion coefficients. We provide a software (available at http://www.RDNets.com) to explore these networks and to constrain topologies with qualitative and quantitative experimental data. We use the software to examine the self-organizing networks that control embryonic axis specification and digit patterning. Finally, we demonstrate how existing synthetic circuits can be extended with additional feedbacks to form Turing reaction-diffusion systems. Our study offers a new theoretical framework to understand multicellular pattern formation and enables the wide-spread use of mathematical biology to engineer synthetic patterning systems.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Diego, Xavier</dc:creator> <dc:creator>Marcon, Luciano</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:creator>Müller, Patrick</dc:creator> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-19T09:47:48Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-19T09:47:48Z</dcterms:available> <dc:contributor>Diego, Xavier</dc:contributor> <dc:rights>Attribution 4.0 International</dc:rights> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/55590"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55590/3/Marcon_2-8pxa9z8gm0it8.pdf"/> <dc:creator>Sharpe, James</dc:creator> </rdf:Description> </rdf:RDF>

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