Dual-Task Performance in GBA Parkinson's Disease

Cite This

Files in this item

Checksum: MD5:6c80eb8c739c6566bfbd96205795263d

SRULIJES, Karin, Kathrin BROCKMANN, Senait OGBAMICAEL, Markus A. HOBERT, Ann-Kathrin HAUSER, Claudia SCHULTE, Jasmin FRITZEN, Michael SCHWENK, Thomas GASSER, Walter MAETZLER, 2017. Dual-Task Performance in GBA Parkinson's Disease. In: Parkinson's disease. Sage-Hindawi, 8582740. ISSN 2090-8083. eISSN 2042-0080. Available under: doi: 10.1155/2017/8582740

@article{Srulijes2017DualT-55583, title={Dual-Task Performance in GBA Parkinson's Disease}, year={2017}, doi={10.1155/2017/8582740}, issn={2090-8083}, journal={Parkinson's disease}, author={Srulijes, Karin and Brockmann, Kathrin and Ogbamicael, Senait and Hobert, Markus A. and Hauser, Ann-Kathrin and Schulte, Claudia and Fritzen, Jasmin and Schwenk, Michael and Gasser, Thomas and Maetzler, Walter}, note={Article Number: 8582740} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/55583"> <dc:creator>Schwenk, Michael</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55583/1/Srulijes_2-bqskmpespdzi8.pdf"/> <dc:creator>Ogbamicael, Senait</dc:creator> <dc:contributor>Srulijes, Karin</dc:contributor> <dc:rights>Attribution 4.0 International</dc:rights> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/35"/> <dc:creator>Fritzen, Jasmin</dc:creator> <dc:creator>Schulte, Claudia</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Maetzler, Walter</dc:creator> <dc:contributor>Fritzen, Jasmin</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Hobert, Markus A.</dc:creator> <dc:contributor>Schwenk, Michael</dc:contributor> <dcterms:title>Dual-Task Performance in GBA Parkinson's Disease</dcterms:title> <dc:creator>Brockmann, Kathrin</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Hauser, Ann-Kathrin</dc:contributor> <dc:contributor>Brockmann, Kathrin</dc:contributor> <dc:creator>Srulijes, Karin</dc:creator> <dcterms:abstract xml:lang="eng">Introduction. Parkinson’s disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson’s disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. Methods. Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck’s Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups. Results. Under the DT condition “walking while checking boxes,” GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs. Conclusion. This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.</dcterms:abstract> <dc:contributor>Maetzler, Walter</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/35"/> <dcterms:issued>2017</dcterms:issued> <dc:contributor>Hobert, Markus A.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-18T11:21:06Z</dcterms:available> <dc:contributor>Ogbamicael, Senait</dc:contributor> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:creator>Hauser, Ann-Kathrin</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-18T11:21:06Z</dc:date> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55583/1/Srulijes_2-bqskmpespdzi8.pdf"/> <dc:contributor>Gasser, Thomas</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/55583"/> <dc:contributor>Schulte, Claudia</dc:contributor> <dc:creator>Gasser, Thomas</dc:creator> </rdf:Description> </rdf:RDF>

Downloads since Nov 18, 2021 (Information about access statistics)

Srulijes_2-bqskmpespdzi8.pdf 17

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account