@article{Zahiri2019Using-55309,
  year={2019},
  doi={10.1016/j.jgo.2019.01.010},
  title={Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults : Toward an early diagnosis of CIPN},
  number={6},
  volume={10},
  issn={1879-4068},
  journal={Journal of geriatric oncology},
  pages={960--967},
  author={Zahiri, Mohsen and Chen, Kevin M. and Zhou, He and Nguyen, Hung and Workeneh, Biruh T. and Yellapragada, Sarvari V. and Sada, Yvonne H. and Schwenk, Michael and Najafi, Bijan}
}

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    <dc:contributor>Nguyen, Hung</dc:contributor>
    <dc:contributor>Workeneh, Biruh T.</dc:contributor>
    <dc:contributor>Najafi, Bijan</dc:contributor>
    <dc:creator>Yellapragada, Sarvari V.</dc:creator>
    <dc:contributor>Sada, Yvonne H.</dc:contributor>
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    <dc:contributor>Yellapragada, Sarvari V.</dc:contributor>
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    <dc:creator>Chen, Kevin M.</dc:creator>
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    <dc:contributor>Zhou, He</dc:contributor>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-10-20T11:37:14Z</dc:date>
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    <dc:creator>Schwenk, Michael</dc:creator>
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    <dc:contributor>Chen, Kevin M.</dc:contributor>
    <dc:contributor>Zahiri, Mohsen</dc:contributor>
    <dcterms:title>Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults : Toward an early diagnosis of CIPN</dcterms:title>
    <dc:creator>Workeneh, Biruh T.</dc:creator>
    <dcterms:issued>2019</dcterms:issued>
    <dc:creator>Zahiri, Mohsen</dc:creator>
    <dc:creator>Nguyen, Hung</dc:creator>
    <dc:contributor>Schwenk, Michael</dc:contributor>
    <dc:creator>Sada, Yvonne H.</dc:creator>
    <dcterms:abstract xml:lang="eng">Objective:&lt;br /&gt;An essential component for optimizing quality of life in adults with cancer is determining the degree to which therapy may negatively impact motor-performance, so that patients can maintain their quality of life and independence. This study examined whether instrumented gait and balance could determine the magnitude of deterioration in motor-performance from chemotherapy-induced peripheral neuropathy (CIPN).&lt;br /&gt;&lt;br /&gt;Methods:&lt;br /&gt;We recruited 84 adults with cancer (age = 71.1 ± 9.7 years old, BMI = 26.8 ± 6.2 kg/m2, gender = 56%female) and 57 age-matched non-cancer patients (age = 69.5 ± 9.8 years old, BMI = 27.1 ± 6.0 kg/m2, gender = 79%female). Based on clinical screening, the group with cancer was classified into two groups: participants with CIPN (CIPN+) and without CIPN (CIPN-). Gait and balance were quantified using validated wearables. The Vibration Perception Threshold (VPT) test was used to stratify the CIPN+ group into mild (Mild-CIPN) and severe (Severe-CIPN) subgroups.&lt;br /&gt;&lt;br /&gt;Results:&lt;br /&gt;All gait and balance parameters were deteriorated in the group with cancer compared to non-cancer group with the largest effects observed for stride-time (11%, Cohen's effect size d = 1.00, p &lt; 0.001) and eyes-closed ankle sway (94%, d = 0.49, p = 0.001). The same trend was observed when the Severe-CIPN subgroup was compared to the Mild-CIPN. VPT correlates significantly with motor deterioration, with the largest correlation found in stride-time (Rho = 0.37, p = 0.007). Severe-CIPN subjects were significantly older and overall had more deterioration in the majority of motor-performance parameters after adjusting for age (p &lt; 0.050).&lt;br /&gt;&lt;br /&gt;Conclusion:&lt;br /&gt;These results confirmed the negative impact of CIPN on motor-performance with the largest effects on ankle stability and stride-time. VPT is a predictor of motor deterioration and may be used to determine the severity of CIPN symptom.</dcterms:abstract>
    <dc:creator>Zhou, He</dc:creator>
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