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Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting

Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting

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ZANDER, Johannes, Stephan SCHOLTES, Maximilian OTTINGER, Marcel KREMER, Azadeh KHARAZI, Vanessa STADLER, Julia BICKMANN, Christian ZELENY, Johannes W. P. KUIPER, Christof R. HAUCK, 2021. Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting. In: Microbiology Spectrum. American Society for Microbiology (ASM). 9(1), e00361-21. eISSN 2165-0497. Available under: doi: 10.1128/Spectrum.00361-21

@article{Zander2021SelfC-55308, title={Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting}, year={2021}, doi={10.1128/Spectrum.00361-21}, number={1}, volume={9}, journal={Microbiology Spectrum}, author={Zander, Johannes and Scholtes, Stephan and Ottinger, Maximilian and Kremer, Marcel and Kharazi, Azadeh and Stadler, Vanessa and Bickmann, Julia and Zeleny, Christian and Kuiper, Johannes W. P. and Hauck, Christof R.}, note={Article Number: e00361-21} }

Kharazi, Azadeh Zander, Johannes Hauck, Christof R. Attribution 4.0 International Kuiper, Johannes W. P. Bickmann, Julia Scholtes, Stephan Scholtes, Stephan Zeleny, Christian Current procurement of specimens for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection requires trained personnel and dedicated equipment. We compared standard nasopharyngeal swabs with self-collected gargle lavage fluid obtained from 80 mostly symptomatic outpatients. After RNA extraction, RT-PCR to detect SARS-CoV-2 was performed. Qualitative results obtained with the paired samples from individual outpatients were 100% congruent. Therefore, self-collected gargle lavage fluid can serve as a suitable specimen for coronavirus disease 2019 (COVID-19) testing in outpatients.<br /><br />IMPORTANCE The SARS-CoV-2 pandemic still strains health care systems worldwide. While COVID-19 testing is considered an essential pillar in combating this infectious disease, shortages in supplies and trained health care personnel often limit the procurement of patient samples, in particular in outpatient settings. Here, we compared the simple self-collection of gargle lavage fluid with the gold standard nasopharyngeal swab as a specimen for COVID-19 testing. By finding complete congruence of results obtained with paired samples of a sizeable patient cohort, our results strongly support the idea that the painless self-collection of gargle lavage fluid provides a suitable and uncomplicated sample for reliable SARS-CoV-2 detection. Kremer, Marcel Self-Collected Gargle Lavage Allows Reliable Detection of SARS-CoV-2 in an Outpatient Setting Zeleny, Christian eng 2021-10-20T11:31:45Z Kremer, Marcel Stadler, Vanessa Kharazi, Azadeh Zander, Johannes Stadler, Vanessa 2021-10-20T11:31:45Z Ottinger, Maximilian Kuiper, Johannes W. P. Hauck, Christof R. Bickmann, Julia Ottinger, Maximilian 2021

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