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The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis

The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis

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HUGHES, Samantha, Henry WILKINSON, Sophie P. R. GILBERT, Marcia KISHIDA, Siyu Serena DING, Alison WOOLLARD, 2014. The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis. In: PLoS one. Public Library of Science (PLoS). 9(12), e114998. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0114998

@article{Hughes2014elega-54403, title={The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis}, year={2014}, doi={10.1371/journal.pone.0114998}, number={12}, volume={9}, journal={PLoS one}, author={Hughes, Samantha and Wilkinson, Henry and Gilbert, Sophie P. R. and Kishida, Marcia and Ding, Siyu Serena and Woollard, Alison}, note={Article Number: e114998} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/54403"> <dc:creator>Hughes, Samantha</dc:creator> <dc:language>eng</dc:language> <dc:creator>Gilbert, Sophie P. R.</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Wilkinson, Henry</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Hughes, Samantha</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54403/3/Hughes_2-1mfktv3ki55iz7.pdf"/> <dc:contributor>Ding, Siyu Serena</dc:contributor> <dc:contributor>Woollard, Alison</dc:contributor> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-07-23T09:15:47Z</dc:date> <dc:creator>Ding, Siyu Serena</dc:creator> <dc:creator>Kishida, Marcia</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">Correct cell fate choice is crucial in development. In post-embryonic development of the hermaphroditic Caenorhabitis elegans, distinct cell fates must be adopted in two diverse tissues. In the germline, stem cells adopt one of three possible fates: mitotic cell cycle, or gamete formation via meiosis, producing either sperm or oocytes. In the epidermis, the stem cell-like seam cells divide asymmetrically, with the daughters taking on either a proliferative (seam) or differentiated (hypodermal or neuronal) fate. We have isolated a novel conserved C. elegans tetratricopeptide repeat containing protein, TRD-1, which is essential for cell fate determination in both the germline and the developing epidermis and has homologs in other species, including humans (TTC27). We show that trd-1(RNAi) and mutant animals have fewer seam cells as a result of inappropriate differentiation towards the hypodermal fate. In the germline, trd-1 RNAi results in a strong masculinization phenotype, as well as defects in the mitosis to meiosis switch. Our data suggests that trd-1 acts downstream of tra-2 but upstream of fem-3 in the germline sex determination pathway, and exhibits a constellation of phenotypes in common with other Mog (masculinization of germline) mutants. Thus, trd-1 is a new player in both the somatic and germline cell fate determination machinery, suggestive of a novel molecular connection between the development of these two diverse tissues.</dcterms:abstract> <dcterms:title>The C. elegans TPR Containing Protein, TRD-1, Regulates Cell Fate Choice in the Developing Germ Line and Epidermis</dcterms:title> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/54403"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54403/3/Hughes_2-1mfktv3ki55iz7.pdf"/> <dc:contributor>Gilbert, Sophie P. R.</dc:contributor> <dcterms:issued>2014</dcterms:issued> <dc:creator>Woollard, Alison</dc:creator> <dc:rights>Attribution 4.0 International</dc:rights> <dc:contributor>Kishida, Marcia</dc:contributor> <dc:contributor>Wilkinson, Henry</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-07-23T09:15:47Z</dcterms:available> </rdf:Description> </rdf:RDF>

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