KOPS - The Institutional Repository of the University of Konstanz

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Cite This

Files in this item

Checksum: MD5:e770c690cd79d442c61ab6f6627d9c38

ASO, Yoshinori, Divya SITARAMAN, Toshiharu ICHINOSE, Karla R. KAUN, Katrin VOGT, Ghislain BELLIART-GUÉRIN, Pierre-Yves PLAÇAIS, Alice A. ROBIE, Nobuhiro YAMAGATA, Gerald M. RUBIN, 2014. Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. In: eLife. eLife Sciences Publications. 3, e04580. eISSN 2050-084X. Available under: doi: 10.7554/eLife.04580

@article{Aso2014-12-23Mushr-54052, title={Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila}, year={2014}, doi={10.7554/eLife.04580}, volume={3}, journal={eLife}, author={Aso, Yoshinori and Sitaraman, Divya and Ichinose, Toshiharu and Kaun, Karla R. and Vogt, Katrin and Belliart-Guérin, Ghislain and Plaçais, Pierre-Yves and Robie, Alice A. and Yamagata, Nobuhiro and Rubin, Gerald M.}, note={Article Number: e04580} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/54052"> <dc:contributor>Aso, Yoshinori</dc:contributor> <dc:creator>Aso, Yoshinori</dc:creator> <dc:contributor>Plaçais, Pierre-Yves</dc:contributor> <dc:creator>Sitaraman, Divya</dc:creator> <dc:contributor>Rubin, Gerald M.</dc:contributor> <dc:creator>Belliart-Guérin, Ghislain</dc:creator> <dc:creator>Vogt, Katrin</dc:creator> <dc:contributor>Robie, Alice A.</dc:contributor> <dc:creator>Ichinose, Toshiharu</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-06-22T08:57:00Z</dc:date> <dc:contributor>Vogt, Katrin</dc:contributor> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:contributor>Sitaraman, Divya</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54052/3/Aso_2-k8p0iebp2zey9.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-06-22T08:57:00Z</dcterms:available> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Plaçais, Pierre-Yves</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Robie, Alice A.</dc:creator> <dc:creator>Kaun, Karla R.</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/54052"/> <dc:contributor>Belliart-Guérin, Ghislain</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/54052/3/Aso_2-k8p0iebp2zey9.pdf"/> <dc:creator>Yamagata, Nobuhiro</dc:creator> <dcterms:abstract xml:lang="eng">Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes. Sensory stimuli are sparsely represented by ∼2000 Kenyon cells, which converge onto 34 output neurons (MBONs) of 21 types. We studied the role of MBONs in several associative learning tasks and in sleep regulation, revealing the extent to which information flow is segregated into distinct channels and suggesting possible roles for the multi-layered MBON network. We also show that optogenetic activation of MBONs can, depending on cell type, induce repulsion or attraction in flies. The behavioral effects of MBON perturbation are combinatorial, suggesting that the MBON ensemble collectively represents valence. We propose that local, stimulus-specific dopaminergic modulation selectively alters the balance within the MBON network for those stimuli. Our results suggest that valence encoded by the MBON ensemble biases memory-based action selection.</dcterms:abstract> <dc:contributor>Kaun, Karla R.</dc:contributor> <dc:contributor>Ichinose, Toshiharu</dc:contributor> <dc:contributor>Yamagata, Nobuhiro</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2014-12-23</dcterms:issued> <dc:rights>Attribution 4.0 International</dc:rights> <dc:creator>Rubin, Gerald M.</dc:creator> </rdf:Description> </rdf:RDF>

Downloads since Jun 22, 2021 (Information about access statistics)

Aso_2-k8p0iebp2zey9.pdf 52

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account