The Role of Astrocytes in the Neurorepair Process

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CHIARELI, Raphaela Almeida, Gustavo Almeida CARVALHO, Bruno Lemes MARQUES, Lennia Soares MOTA, Onésia Cristina OLIVEIRA-LIMA, Rodrigo Mello GOMES, Alexander BIRBRAIR, Renato Santiago GOMEZ, Marcel LEIST, Mauro Cunha Xavier PINTO, 2021. The Role of Astrocytes in the Neurorepair Process. In: Frontiers in Cell and Developmental Biology. Frontiers Media. 9, 665795. eISSN 2296-634X. Available under: doi: 10.3389/fcell.2021.665795

@article{Chiareli2021-05-25Astro-53968, title={The Role of Astrocytes in the Neurorepair Process}, year={2021}, doi={10.3389/fcell.2021.665795}, volume={9}, journal={Frontiers in Cell and Developmental Biology}, author={Chiareli, Raphaela Almeida and Carvalho, Gustavo Almeida and Marques, Bruno Lemes and Mota, Lennia Soares and Oliveira-Lima, Onésia Cristina and Gomes, Rodrigo Mello and Birbrair, Alexander and Gomez, Renato Santiago and Leist, Marcel and Pinto, Mauro Cunha Xavier}, note={Article Number: 665795} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:rights>Attribution 4.0 International</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Gomes, Rodrigo Mello</dc:contributor> <dcterms:available rdf:datatype="">2021-06-14T10:47:59Z</dcterms:available> <dc:date rdf:datatype="">2021-06-14T10:47:59Z</dc:date> <dc:creator>Mota, Lennia Soares</dc:creator> <dc:language>eng</dc:language> <dc:creator>Gomes, Rodrigo Mello</dc:creator> <dc:creator>Pinto, Mauro Cunha Xavier</dc:creator> <dcterms:hasPart rdf:resource=""/> <dc:contributor>Mota, Lennia Soares</dc:contributor> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Carvalho, Gustavo Almeida</dc:contributor> <dc:contributor>Birbrair, Alexander</dc:contributor> <dc:contributor>Chiareli, Raphaela Almeida</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:creator>Leist, Marcel</dc:creator> <dc:creator>Carvalho, Gustavo Almeida</dc:creator> <dc:contributor>Pinto, Mauro Cunha Xavier</dc:contributor> <dcterms:abstract xml:lang="eng">Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and metabolism, the modulation of synaptic activity by capturing and recycle of neurotransmitters and maintenance of the blood-brain barrier. During injuries and infections, astrocytes act in cerebral defense through heterogeneous and progressive changes in their gene expression, morphology, proliferative capacity, and function, which is known as reactive astrocytes. Thus, reactive astrocytes release several signaling molecules that modulates and contributes to the defense against injuries and infection in the central nervous system. Therefore, deciphering the complex signaling pathways of reactive astrocytes after brain damage can contribute to the neuroinflammation control and reveal new molecular targets to stimulate neurorepair process. In this review, we present the current knowledge about the role of astrocytes in brain damage and repair, highlighting the cellular and molecular bases involved in synaptogenesis and neurogenesis. In addition, we present new approaches to modulate the astrocytic activity and potentiates the neurorepair process after brain damage.</dcterms:abstract> <dc:creator>Oliveira-Lima, Onésia Cristina</dc:creator> <dc:creator>Birbrair, Alexander</dc:creator> <dc:contributor>Gomez, Renato Santiago</dc:contributor> <dcterms:issued>2021-05-25</dcterms:issued> <dcterms:rights rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dcterms:title>The Role of Astrocytes in the Neurorepair Process</dcterms:title> <dc:creator>Gomez, Renato Santiago</dc:creator> <dc:contributor>Marques, Bruno Lemes</dc:contributor> <dc:creator>Marques, Bruno Lemes</dc:creator> <dc:creator>Chiareli, Raphaela Almeida</dc:creator> <dc:contributor>Oliveira-Lima, Onésia Cristina</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> </rdf:Description> </rdf:RDF>

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