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Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

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ZWICKER, Felix, Sebastian HÖFEL, Corinna KIRCHNER, Peter E. HUBER, Jürgen DEBUS, Michael SCHEMPP, 2021. Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge. In: Anticancer research. Stanford University Highwire Press. 41(4), pp. 1909-1920. ISSN 0250-7005. eISSN 1791-7530. Available under: doi: 10.21873/anticanres.14957

@article{Zwicker2021-04Hypof-53617, title={Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge}, year={2021}, doi={10.21873/anticanres.14957}, number={4}, volume={41}, issn={0250-7005}, journal={Anticancer research}, pages={1909--1920}, author={Zwicker, Felix and Höfel, Sebastian and Kirchner, Corinna and Huber, Peter E. and Debus, Jürgen and Schempp, Michael} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/53617"> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/53617"/> <dcterms:abstract xml:lang="eng">This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined.Background/Aim: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined. Patients and Methods: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values. Results: The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. Conclusion: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-05-06T14:26:57Z</dcterms:available> <dcterms:title>Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge</dcterms:title> <dc:contributor>Huber, Peter E.</dc:contributor> <dc:contributor>Schempp, Michael</dc:contributor> <dc:creator>Höfel, Sebastian</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:issued>2021-04</dcterms:issued> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-05-06T14:26:57Z</dc:date> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Zwicker, Felix</dc:contributor> <dc:creator>Zwicker, Felix</dc:creator> <dc:contributor>Kirchner, Corinna</dc:contributor> <dc:creator>Schempp, Michael</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Kirchner, Corinna</dc:creator> <dc:creator>Huber, Peter E.</dc:creator> <dc:language>eng</dc:language> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53617/1/Zwicker_%202-kz2sn64tac6m5.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:contributor>Höfel, Sebastian</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Debus, Jürgen</dc:creator> <dc:contributor>Debus, Jürgen</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53617/1/Zwicker_%202-kz2sn64tac6m5.pdf"/> </rdf:Description> </rdf:RDF>

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