Giant lungfish genome elucidates the conquest of land by vertebrates

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MEYER, Axel, Siegfried SCHLOISSNIG, Paolo FRANCHINI, Joost M. WOLTERING, Iker IRISARRI, Peiwen XIONG, Oleg SIMAKOV, Thorsten BURMESTER, Elly M. TANAKA, Manfred SCHARTL, 2021. Giant lungfish genome elucidates the conquest of land by vertebrates. In: Nature. Springer Nature. 590, pp. 284-289. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/s41586-021-03198-8

@article{Meyer2021-01-18Giant-53183, title={Giant lungfish genome elucidates the conquest of land by vertebrates}, year={2021}, doi={10.1038/s41586-021-03198-8}, volume={590}, issn={0028-0836}, journal={Nature}, pages={284--289}, author={Meyer, Axel and Schloissnig, Siegfried and Franchini, Paolo and Woltering, Joost M. and Irisarri, Iker and Xiong, Peiwen and Simakov, Oleg and Burmester, Thorsten and Tanaka, Elly M. and Schartl, Manfred} }

Attribution 4.0 International Simakov, Oleg Simakov, Oleg Woltering, Joost M. Franchini, Paolo Meyer, Axel 2021-01-18 Tanaka, Elly M. Irisarri, Iker Burmester, Thorsten 2021-03-18T08:25:31Z Schartl, Manfred Schartl, Manfred Giant lungfish genome elucidates the conquest of land by vertebrates Lungfishes belong to lobe-fined fish (Sarcopterygii) that in the Devonian 'conquered' land and gave rise to all land vertebrates, including humans1-3. We determined the largest chromosome-quality animal genome, the Australian lungfish, Neoceratodus forsteri. Its vast size (~14x of human) is attributable mostly to huge intergenic regions and introns with high repeat content (≈90%) whose components resemble tetrapods more (mostly LINE elements) than ray-finned fish. The lungfish genome continues to expand (its TEs are still active) independently and by different mechanisms than enormous salamander genomes. Synteny to other vertebrate chromosomes of 17 fully assembled macrochromosomes is maintained just as its conserved ancient homology of all microchromosomes to the ancestral vertebrate karyotype. Phylogenomic analyses ascertained that lungfish occupy an evolutionary key-position as closest living relatives to tetrapods, underscoring their importance for understanding innovations associated with terrestrialization<sup>4,5</sup>. Preadaptations to living on land include gaining of limb-like expression of developmental genes such as hoxc13 and sall1 in their lobed fins. Increased rates of evolution and duplication of genes associated with obligate air-breathing such as lung surfactants and the expansion of odorant receptor gene-families that detect airborne odours contribute to their tetrapod-like biology. These findings advance our understanding of this major transition during vertebrate evolution. 2021-03-18T08:25:31Z Tanaka, Elly M. Burmester, Thorsten Irisarri, Iker eng Franchini, Paolo Schloissnig, Siegfried Meyer, Axel Xiong, Peiwen Xiong, Peiwen Woltering, Joost M. Schloissnig, Siegfried

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