KOPS - The Institutional Repository of the University of Konstanz

Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

MARCHANT, Nathan J., Erin J. CAMPBELL, Leslie R. WHITAKER, Brandon K. HARVEY, Konstantin KAGANOVSKY, Sweta ADHIKARY, Bruce T. HOPE, Robert C. HEINS, Thomas E. PRISINZANO, Yavin SHAHAM, 2016. Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence. In: The Journal of Neuroscience. Society for Neuroscience. 36(11), pp. 3281-3294. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.4299-15.2016

@article{Marchant2016-03-16Ventr-52063, title={Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence}, year={2016}, doi={10.1523/JNEUROSCI.4299-15.2016}, number={11}, volume={36}, issn={0270-6474}, journal={The Journal of Neuroscience}, pages={3281--3294}, author={Marchant, Nathan J. and Campbell, Erin J. and Whitaker, Leslie R. and Harvey, Brandon K. and Kaganovsky, Konstantin and Adhikary, Sweta and Hope, Bruce T. and Heins, Robert C. and Prisinzano, Thomas E. and Shaham, Yavin} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/52063"> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/52063"/> <dc:contributor>Heins, Robert C.</dc:contributor> <dc:contributor>Whitaker, Leslie R.</dc:contributor> <dc:creator>Whitaker, Leslie R.</dc:creator> <dc:contributor>Harvey, Brandon K.</dc:contributor> <dc:creator>Shaham, Yavin</dc:creator> <dc:creator>Kaganovsky, Konstantin</dc:creator> <dcterms:title>Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence</dcterms:title> <dc:contributor>Hope, Bruce T.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Adhikary, Sweta</dc:creator> <dc:contributor>Prisinzano, Thomas E.</dc:contributor> <dc:creator>Prisinzano, Thomas E.</dc:creator> <dc:creator>Heins, Robert C.</dc:creator> <dc:contributor>Adhikary, Sweta</dc:contributor> <dc:creator>Harvey, Brandon K.</dc:creator> <dcterms:issued>2016-03-16</dcterms:issued> <dc:contributor>Shaham, Yavin</dc:contributor> <dc:contributor>Campbell, Erin J.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-12-09T13:00:14Z</dcterms:available> <dcterms:abstract xml:lang="eng">In many human alcoholics, abstinence is self-imposed because of the negative consequences of excessive alcohol use, and relapse is often triggered by exposure to environmental contexts associated with prior alcohol drinking. We recently developed a rat model of this human condition in which we train alcohol-preferring P rats to self-administer alcohol in one context (A), punish the alcohol-reinforced responding in a different context (B), and then test for relapse to alcohol seeking in Contexts A and B without alcohol or shock. Here, we studied the role of projections to nucleus accumbens (NAc) shell from ventral subiculum (vSub), basolateral amygdala, paraventricular thalamus, and ventral medial prefrontal cortex in context-induced relapse after punishment-imposed abstinence. First, we measured double-labeling of the neuronal activity marker Fos with the retrograde tracer cholera toxin subunit B (injected in NAc shell) and demonstrated that context-induced relapse is associated with selective activation of the vSub→NAc shell projection. Next, we reversibly inactivated the vSub with GABA receptor agonists (muscimol+baclofen) before the context-induced relapse tests and provided evidence for a causal role of vSub in this relapse. Finally, we used a dual-virus approach to restrict expression of the inhibitory κ opioid-receptor based DREADD (KORD) in vSub→NAc shell projection neurons. We found that systemic injections of the KORD agonist salvinorin B, which selectively inhibits KORD-expressing neurons, decreased context-induced relapse to alcohol seeking. Our results demonstrate a critical role of vSub in context-induced relapse after punishment-imposed abstinence and further suggest a role of the vSub→NAc projection in this relapse.</dcterms:abstract> <dc:creator>Hope, Bruce T.</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:contributor>Kaganovsky, Konstantin</dc:contributor> <dc:contributor>Marchant, Nathan J.</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:creator>Campbell, Erin J.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-12-09T13:00:14Z</dc:date> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:creator>Marchant, Nathan J.</dc:creator> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account