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Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation

Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation

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JOHANSSON, Ann-Sofi, Jonas BERGQUIST, Christiane VOLBRACHT, Anna PÄIVIÖ, Marcel LEIST, Lars LANNFELT, Anita WESTLIND-DANIELSSON, 2007. Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation. In: Neuroreport. Lippincott Williams & Wilkins. 18(6), pp. 559-563. ISSN 0959-4965. eISSN 1473-558X. Available under: doi: 10.1097/WNR.0b013e3280b07c21

@article{Johansson2007-04-16Atten-52016, title={Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation}, year={2007}, doi={10.1097/WNR.0b013e3280b07c21}, number={6}, volume={18}, issn={0959-4965}, journal={Neuroreport}, pages={559--563}, author={Johansson, Ann-Sofi and Bergquist, Jonas and Volbracht, Christiane and Päiviö, Anna and Leist, Marcel and Lannfelt, Lars and Westlind-Danielsson, Anita} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/52016"> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Westlind-Danielsson, Anita</dc:creator> <dc:contributor>Lannfelt, Lars</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:title>Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation</dcterms:title> <dc:contributor>Johansson, Ann-Sofi</dc:contributor> <dc:creator>Volbracht, Christiane</dc:creator> <dcterms:abstract xml:lang="eng">Aggregation of the amyloid-beta (Abeta) peptide into amyloid plaques is a characteristic feature of Alzheimer's disease neuropathogenesis. We and others have previously demonstrated delayed Abeta aggregation as a consequence of oxidizing a single methionine residue at position 35 (Met-35). Here, we examined the consequences of Met-35 oxidation on the extremely aggregation-prone peptides Abeta1-42 and Abeta1-40Arctic with respect to protofibril and oligomer formation as well as neurotoxicity. Size exclusion chromatography and mass spectrometry demonstrated that monomer/dimers prevailed over larger oligomers after oxidizing Met-35, and consequently protofibril formation and aggregation of both Abeta1-42 and Abeta1-40Arctic were delayed. The oxidized peptides completely lacked neurotoxic effects in cortical neuronal cultures under these conditions, in contrast to the neurotoxic properties of the unoxidized peptides. We conclude that oxidation of Met-35 significantly attenuates aggregation of Abeta1-42 and Abeta1-40Arctic, and thereby reduces neurotoxicity.</dcterms:abstract> <dcterms:issued>2007-04-16</dcterms:issued> <dc:language>eng</dc:language> <dc:creator>Lannfelt, Lars</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/52016"/> <dc:creator>Bergquist, Jonas</dc:creator> <dc:creator>Päiviö, Anna</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-12-07T08:13:34Z</dc:date> <dc:creator>Leist, Marcel</dc:creator> <dc:contributor>Westlind-Danielsson, Anita</dc:contributor> <dc:contributor>Päiviö, Anna</dc:contributor> <dc:contributor>Volbracht, Christiane</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Johansson, Ann-Sofi</dc:creator> <dc:rights>terms-of-use</dc:rights> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-12-07T08:13:34Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Bergquist, Jonas</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> </rdf:Description> </rdf:RDF>

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