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Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice

Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice

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GOLDEN, Sam A., Hossein ALEYASIN, Conor HEINS, Meghan FLANIGAN, Mitra HESHMATI, Aki TAKAHASHI, Scott J. RUSSO, Yavin SHAHAM, 2017. Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. In: Genes, Brain and Behavior. Wiley. 16(1), pp. 44-55. ISSN 1601-1848. eISSN 1601-183X. Available under: doi: 10.1111/gbb.12310

@article{Golden2017-01Persi-51716, title={Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice}, year={2017}, doi={10.1111/gbb.12310}, number={1}, volume={16}, issn={1601-1848}, journal={Genes, Brain and Behavior}, pages={44--55}, author={Golden, Sam A. and Aleyasin, Hossein and Heins, Conor and Flanigan, Meghan and Heshmati, Mitra and Takahashi, Aki and Russo, Scott J. and Shaham, Yavin} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/51716"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-11-09T14:56:17Z</dc:date> <dc:contributor>Shaham, Yavin</dc:contributor> <dcterms:abstract xml:lang="eng">We recently developed a conditioned place preference (CPP) procedure, commonly used to study rewarding drug effects, to demonstrate that dominant sexually-experienced CD-1 male mice form CPP to contexts previously associated with defeating subordinate male C57BL/6J mice. Here we further characterized conditioned and unconditioned aggression behavior in CD-1 mice. In Exp. 1 we used CD-1 mice that displayed a variable spectrum of unconditioned aggressive behavior toward younger subordinate C57BL/6J intruder mice. We then trained the CD-1 mice in the CPP procedure where one context was intruder-paired, while a different context was not. We then tested for aggression CPP 1 day after training. In Exp. 2, we tested CD-1 mice for aggression CPP 1 day and 18 days after training. In Exp. 3-4, we trained the CD-1 mice to lever-press for palatable food and tested them for footshock punishment-induced suppression of food-reinforced responding. In Exp. 5, we characterized unconditioned aggression in hybrid CD-1 × C57BL/6J D1-Cre or D2-Cre F1 generation crosses. Persistent aggression CPP was observed in CD-1 mice that either immediately attacked C57BL/6J mice during all screening sessions or mice that gradually developed aggressive behavior during the screening phase. In contrast, CD-1 mice that did not attack the C57BL/6J mice during screening did not develop CPP to contexts previously paired with C57BL/6J mice. The aggressive phenotype did not predict resistance to punishment-induced suppression of food-reinforced responding. CD-1 × D1-Cre or D2-Cre F1 transgenic mice showed strong unconditioned aggression. Our study demonstrates that aggression experience causes persistent CPP and introduces transgenic mice for circuit studies of aggression.</dcterms:abstract> <dc:creator>Shaham, Yavin</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Heshmati, Mitra</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:contributor>Takahashi, Aki</dc:contributor> <dc:creator>Heins, Conor</dc:creator> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Golden, Sam A.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Heins, Conor</dc:contributor> <dc:creator>Aleyasin, Hossein</dc:creator> <dcterms:issued>2017-01</dcterms:issued> <dc:contributor>Flanigan, Meghan</dc:contributor> <dcterms:title>Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice</dcterms:title> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51716"/> <dc:contributor>Aleyasin, Hossein</dc:contributor> <dc:contributor>Golden, Sam A.</dc:contributor> <dc:creator>Takahashi, Aki</dc:creator> <dc:contributor>Heshmati, Mitra</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-11-09T14:56:17Z</dcterms:available> <dc:creator>Flanigan, Meghan</dc:creator> <dc:contributor>Russo, Scott J.</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Russo, Scott J.</dc:creator> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>

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