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Type of Publication: | Journal article |
Publication status: | Published |
Author: | Golden, Sam A.; Aleyasin, Hossein; Heins, Conor; Flanigan, Meghan; Heshmati, Mitra; Takahashi, Aki; Russo, Scott J.; Shaham, Yavin |
Year of publication: | 2017 |
Published in: | Genes, Brain and Behavior ; 16 (2017), 1. - pp. 44-55. - Wiley. - ISSN 1601-1848. - eISSN 1601-183X |
Pubmed ID: | 27457669 |
DOI (citable link): | https://dx.doi.org/10.1111/gbb.12310 |
Summary: |
We recently developed a conditioned place preference (CPP) procedure, commonly used to study rewarding drug effects, to demonstrate that dominant sexually-experienced CD-1 male mice form CPP to contexts previously associated with defeating subordinate male C57BL/6J mice. Here we further characterized conditioned and unconditioned aggression behavior in CD-1 mice. In Exp. 1 we used CD-1 mice that displayed a variable spectrum of unconditioned aggressive behavior toward younger subordinate C57BL/6J intruder mice. We then trained the CD-1 mice in the CPP procedure where one context was intruder-paired, while a different context was not. We then tested for aggression CPP 1 day after training. In Exp. 2, we tested CD-1 mice for aggression CPP 1 day and 18 days after training. In Exp. 3-4, we trained the CD-1 mice to lever-press for palatable food and tested them for footshock punishment-induced suppression of food-reinforced responding. In Exp. 5, we characterized unconditioned aggression in hybrid CD-1 × C57BL/6J D1-Cre or D2-Cre F1 generation crosses. Persistent aggression CPP was observed in CD-1 mice that either immediately attacked C57BL/6J mice during all screening sessions or mice that gradually developed aggressive behavior during the screening phase. In contrast, CD-1 mice that did not attack the C57BL/6J mice during screening did not develop CPP to contexts previously paired with C57BL/6J mice. The aggressive phenotype did not predict resistance to punishment-induced suppression of food-reinforced responding. CD-1 × D1-Cre or D2-Cre F1 transgenic mice showed strong unconditioned aggression. Our study demonstrates that aggression experience causes persistent CPP and introduces transgenic mice for circuit studies of aggression.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Aggression, CD‐1, conditioned place preference, D1‐Cre, D2‐Cre, food self‐administration, mice, punishment, reward |
Refereed: | Yes |
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GOLDEN, Sam A., Hossein ALEYASIN, Conor HEINS, Meghan FLANIGAN, Mitra HESHMATI, Aki TAKAHASHI, Scott J. RUSSO, Yavin SHAHAM, 2017. Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. In: Genes, Brain and Behavior. Wiley. 16(1), pp. 44-55. ISSN 1601-1848. eISSN 1601-183X. Available under: doi: 10.1111/gbb.12310
@article{Golden2017-01Persi-51716, title={Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice}, year={2017}, doi={10.1111/gbb.12310}, number={1}, volume={16}, issn={1601-1848}, journal={Genes, Brain and Behavior}, pages={44--55}, author={Golden, Sam A. and Aleyasin, Hossein and Heins, Conor and Flanigan, Meghan and Heshmati, Mitra and Takahashi, Aki and Russo, Scott J. and Shaham, Yavin} }
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