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Volitional social interaction prevents drug addiction in rat models

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VENNIRO, Marco, Michelle ZHANG, Daniele CAPRIOLI, Jennifer K. HOOTS, Sam A. GOLDEN, Conor HEINS, Marisela MORALES, David H. EPSTEIN, Yavin SHAHAM, 2018. Volitional social interaction prevents drug addiction in rat models. In: Nature Neuroscience. Nature Publishing Group. 21(11), pp. 1520-1529. ISSN 1097-6256. eISSN 1546-1726. Available under: doi: 10.1038/s41593-018-0246-6

@article{Venniro2018Volit-51715, title={Volitional social interaction prevents drug addiction in rat models}, year={2018}, doi={10.1038/s41593-018-0246-6}, number={11}, volume={21}, issn={1097-6256}, journal={Nature Neuroscience}, pages={1520--1529}, author={Venniro, Marco and Zhang, Michelle and Caprioli, Daniele and Hoots, Jennifer K. and Golden, Sam A. and Heins, Conor and Morales, Marisela and Epstein, David H. and Shaham, Yavin} }

Epstein, David H. 2020-11-09T14:48:26Z Caprioli, Daniele Zhang, Michelle Morales, Marisela Caprioli, Daniele Venniro, Marco 2020-11-09T14:48:26Z Zhang, Michelle Heins, Conor Volitional social interaction prevents drug addiction in rat models Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCδ-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments. Venniro, Marco eng Shaham, Yavin Golden, Sam A. Hoots, Jennifer K. Heins, Conor 2018 Epstein, David H. Shaham, Yavin terms-of-use Golden, Sam A. Morales, Marisela Hoots, Jennifer K.

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