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Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity

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Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity

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HUANG, Zixia, Conor V. WHELAN, Dina K. N. DECHMANN, Emma C. TEELING, 2020. Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity. In: Aging. Impact Journals. 12(16), pp. 15962-15977. eISSN 1945-4589. Available under: doi: 10.18632/aging.103725

@article{Huang2020-09-05Genet-51160, title={Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity}, year={2020}, doi={10.18632/aging.103725}, number={16}, volume={12}, journal={Aging}, pages={15962--15977}, author={Huang, Zixia and Whelan, Conor V. and Dechmann, Dina K. N. and Teeling, Emma C.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/51160"> <dc:contributor>Huang, Zixia</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51160"/> <dcterms:issued>2020-09-05</dcterms:issued> <dc:contributor>Teeling, Emma C.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-01T13:49:32Z</dcterms:available> <dc:contributor>Dechmann, Dina K. N.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51160/1/Huang_2-waqtl1amaw481pdf.pdf"/> <dc:creator>Huang, Zixia</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-01T13:49:32Z</dc:date> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/3.0/"/> <dc:contributor>Whelan, Conor V.</dc:contributor> <dcterms:title>Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity</dcterms:title> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51160/1/Huang_2-waqtl1amaw481pdf.pdf"/> <dc:creator>Dechmann, Dina K. N.</dc:creator> <dcterms:abstract xml:lang="eng">Bats are the longest-lived mammals given their body size with majority of species exhibiting exceptional longevity. However, there are some short-lived species that do not exhibit extended lifespans. Here we conducted a comparative genomic and transcriptomic study on long-lived Myotis myotis (maximum lifespan = 37.1 years) and short-lived Molossus molossus (maximum lifespan = 5.6 years) to ascertain the genetic difference underlying their divergent longevities. Genome-wide selection tests on 12,467 single-copy genes between M. myotis and M. molossus revealed only three genes (CCDC175, FATE1 and MLKL) that exhibited significant positive selection. Although 97.96% of 12,467 genes underwent purifying selection, we observed a significant heterogeneity in their expression patterns. Using a linear mixed model, we obtained expression of 2,086 genes that may truly represent the genetic difference between M. myotis and M. molossus. Expression analysis indicated that long-lived M. myotis exhibited a transcriptomic profile of enhanced DNA repair and autophagy pathways, compared to M. molossus. Further investigation of the longevity-associated genes suggested that long-lived M. myotis have naturally evolved a diminished anti-longevity transcriptomic profile. Together with observations from other long-lived species, our results suggest that heightened DNA repair and autophagy activity may represent a universal mechanism to achieve longevity in long-lived mammals.</dcterms:abstract> <dc:creator>Teeling, Emma C.</dc:creator> <dc:creator>Whelan, Conor V.</dc:creator> <dc:rights>Attribution 3.0 Unported</dc:rights> </rdf:Description> </rdf:RDF>

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