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Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways

Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways

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GRUBER, Andreas J., William A. GRANDY, Piotr J. BALWIERZ, Yoana A. DIMITROVA, Mikhail PACHKOV, Constance CIAUDO, Erik van NIMWEGEN, Mihaela ZAVOLAN, 2014. Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways. In: Nucleic acids research. PubMed Central. 42(14), pp. 9313-9326. ISSN 0301-5610. eISSN 1362-4962. Available under: doi: 10.1093/nar/gku544

@article{Gruber2014-08Embry-51017, title={Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways}, year={2014}, doi={10.1093/nar/gku544}, number={14}, volume={42}, issn={0301-5610}, journal={Nucleic acids research}, pages={9313--9326}, author={Gruber, Andreas J. and Grandy, William A. and Balwierz, Piotr J. and Dimitrova, Yoana A. and Pachkov, Mikhail and Ciaudo, Constance and Nimwegen, Erik van and Zavolan, Mihaela} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/51017"> <dc:language>eng</dc:language> <dc:contributor>Dimitrova, Yoana A.</dc:contributor> <dc:creator>Gruber, Andreas J.</dc:creator> <dc:creator>Zavolan, Mihaela</dc:creator> <dc:contributor>Balwierz, Piotr J.</dc:contributor> <dc:rights>Attribution-NonCommercial 4.0 International</dc:rights> <dc:contributor>Zavolan, Mihaela</dc:contributor> <dc:contributor>Pachkov, Mikhail</dc:contributor> <dc:creator>Nimwegen, Erik van</dc:creator> <dc:creator>Dimitrova, Yoana A.</dc:creator> <dcterms:title>Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51017"/> <dc:contributor>Gruber, Andreas J.</dc:contributor> <dc:creator>Grandy, William A.</dc:creator> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc/4.0/"/> <dc:contributor>Grandy, William A.</dc:contributor> <dc:creator>Ciaudo, Constance</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-24T11:16:07Z</dcterms:available> <dc:contributor>Nimwegen, Erik van</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Balwierz, Piotr J.</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51017/3/Gruber_2-1q3rr0vk799kr4.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/51017/3/Gruber_2-1q3rr0vk799kr4.pdf"/> <dcterms:issued>2014-08</dcterms:issued> <dcterms:abstract xml:lang="eng">The findings that microRNAs (miRNAs) are essential for early development in many species and that embryonic miRNAs can reprogram somatic cells into induced pluripotent stem cells suggest that these miRNAs act directly on transcriptional and chromatin regulators of pluripotency. To elucidate the transcription regulatory networks immediately downstream of embryonic miRNAs, we extended the motif activity response analysis approach that infers the regulatory impact of both transcription factors (TFs) and miRNAs from genome-wide expression states. Applying this approach to multiple experimental data sets generated from mouse embryonic stem cells (ESCs) that did or did not express miRNAs of the ESC-specific miR-290-295 cluster, we identified multiple TFs that are direct miRNA targets, some of which are known to be active during cell differentiation. Our results provide new insights into the transcription regulatory network downstream of ESC-specific miRNAs, indicating that these miRNAs act on cell cycle and chromatin regulators at several levels and downregulate TFs that are involved in the innate immune response.</dcterms:abstract> <dc:creator>Pachkov, Mikhail</dc:creator> <dc:contributor>Ciaudo, Constance</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-24T11:16:07Z</dc:date> </rdf:Description> </rdf:RDF>

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