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Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm

Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm

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WOLFSTETTER, Georg, Margret SHIRINIAN, Christiana STUTE, Caroline GRABBE, Thomas HUMMEL, Stefan BAUMGARTNER, Ruth H. PALMER, Anne HOLZ, 2009. Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm. In: Mechanisms of Development. Elsevier. 126(8-9), pp. 721-736. ISSN 0925-4773. eISSN 1872-6356. Available under: doi: 10.1016/j.mod.2009.05.001

@article{Wolfstetter2009-08Fusio-50935, title={Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm}, year={2009}, doi={10.1016/j.mod.2009.05.001}, number={8-9}, volume={126}, issn={0925-4773}, journal={Mechanisms of Development}, pages={721--736}, author={Wolfstetter, Georg and Shirinian, Margret and Stute, Christiana and Grabbe, Caroline and Hummel, Thomas and Baumgartner, Stefan and Palmer, Ruth H. and Holz, Anne} }

Holz, Anne terms-of-use Shirinian, Margret eng 2009-08 Baumgartner, Stefan Hummel, Thomas Baumgartner, Stefan In this study we describe the morphological and genetic analysis of the Drosophila mutant gürtelchen (gurt). gurt was identified by screening an EMS collection for novel mutations affecting visceral mesoderm development and was named after the distinct belt shaped visceral phenotype. Interestingly, determination of visceral cell identities and subsequent visceral myoblast fusion is not affected in mutant embryos indicating a later defect in visceral development. gurt is in fact a new huckebein (hkb) allele and as such exhibits nearly complete loss of endodermal derived structures. Targeted ablation of the endodermal primordia produces a phenotype that resembles the visceral defects observed in huckebein<sup>gürtelchen</sup> (hkb<sup>gurt</sup>) mutant embryos. It was shown previously that visceral mesoderm development requires complex interactions between visceral myoblasts and adjacent tissues. Signals from the neighbouring somatic myoblasts play an important role in cell type determination and are a prerequisite for visceral muscle fusion. Furthermore, the visceral mesoderm is known to influence endodermal migration and midgut epithelium formation. Our analyses of the visceral phenotype of hkb<sup>gurt</sup> mutant embryos reveal that the adjacent endoderm plays a critical role in the later stages of visceral muscle development, and is required for visceral muscle elongation and outgrowth after proper myoblast fusion. Hummel, Thomas Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm Palmer, Ruth H. Palmer, Ruth H. Holz, Anne Stute, Christiana Stute, Christiana Grabbe, Caroline Grabbe, Caroline 2020-09-22T07:28:04Z Wolfstetter, Georg Wolfstetter, Georg Shirinian, Margret 2020-09-22T07:28:04Z

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