Journal article:
NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

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Date
September 1, 2020
Editors
Vukojevic, Vanja
Coynel, David
Ghaffari, Navid R.
Freytag, Virginie
Wilker, Sarah
McGaugh, James L.
Papassotiropoulos, Andreas
de Quervain, Dominique J.-F.
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Abstract
Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (n = 463) and survivors of the Rwandan genocide (n = 350). The strongest link between regional methylation and PTSD risk and symptoms was observed for NTRK2, which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an important role in memory formation. NTRK2 methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Because NTRK2 methylation differences were predominantly associated with memory-related PTSD symptoms, and because they seem to precede traumatic events, we next investigated the relationship between NTRK2 methylation and memory in a sample of nontraumatized individuals (n = 568). We found that NTRK2 methylation was negatively associated with recognition memory performance. Furthermore, fMRI analyses revealed NTRK2 methylation-dependent differences in brain network activity related to recognition memory. The present study demonstrates that NTRK2 is epigenetically linked to memory functions in nontraumatized subjects and to PTSD risk and symptoms in traumatized populations.
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150 Psychology
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PTSD, glucocorticoids, memory, epigenetics, NTRK2
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Proceedings of the National Academy of Sciences of the United States of America ; 117 (2020), 35. - pp. 21667-21672. - National Academy of Sciences. - ISSN 0027-8424. - eISSN 1091-6490
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ISO 690VUKOJEVIC, Vanja, David COYNEL, Navid R. GHAFFARI, Virginie FREYTAG, Thomas ELBERT, Iris-Tatjana KOLASSA, Sarah WILKER, James L. MCGAUGH, Andreas PAPASSOTIROPOULOS, Dominique J.-F. DE QUERVAIN, 2020. NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. In: Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. 117(35), pp. 21667-21672. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.2008415117
BibTex
@article{Vukojevic2020-09-01NTRK2-50771,
  year={2020},
  doi={10.1073/pnas.2008415117},
  title={NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors},
  number={35},
  volume={117},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={21667--21672},
  author={Vukojevic, Vanja and Coynel, David and Ghaffari, Navid R. and Freytag, Virginie and Elbert, Thomas and Kolassa, Iris-Tatjana and Wilker, Sarah and McGaugh, James L. and Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.}
}
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