Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer
| Type of Publication: | Journal article |
| Publication status: | Published |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1j8zpmn77jj904 |
| Author: | Michalek, Svenja; Brunner, Thomas |
| Year of publication: | 2021 |
| Published in: | IUBMB Life ; 73 (2021), 3. - pp. 592-610. - Wiley. - eISSN 1521-6551 |
| DOI (citable link): | https://dx.doi.org/10.1002/iub.2386 |
| Summary: |
Liver receptor homolog-1 (LRH-1, NR5A2) is an orphan nuclear receptor with widespread activities in the regulation of development, stemness, metabolism, steroidogenesis, and proliferation. Many of the LRH-1-regulated processes target the mitochondria and associated activities. While under physiological conditions, a balanced LRH-1 expression and regulation contribute to the maintenance of a physiological equilibrium, deregulation of LRH-1 has been associated with inflammation and cancer. In this review, we discuss the role and mechanism(s) of how LRH-1 regulates metabolic processes, cell survival, and cancer in a nuclear-mitochondrial crosstalk, and evaluate its potential as a pharmacological target.
|
| Subject (DDC): | 570 Biosciences, Biology |
| Link to License: | Attribution-NonCommercial-NoDerivatives 4.0 International |
| Bibliography of Konstanz: | Yes |
| Refereed: | Yes |
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MICHALEK, Svenja, Thomas BRUNNER, 2021. Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer. In: IUBMB Life. Wiley. 73(3), pp. 592-610. eISSN 1521-6551. Available under: doi: 10.1002/iub.2386
@article{Michalek2021Nucle-50733, title={Nuclear-mitochondrial crosstalk : on the role of the nuclear receptor Liver Receptor Homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival and cancer}, year={2021}, doi={10.1002/iub.2386}, number={3}, volume={73}, journal={IUBMB Life}, pages={592--610}, author={Michalek, Svenja and Brunner, Thomas} }
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