The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

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Datum
2020
Autor:innen
Lupu, Diana
Andersson, Patrik
Bornehag, Carl-Gustaf
Demeneix, Barbara
Fritsche, Ellen
Gennings, Chris
Lichtensteiger, Walter
Leonards, Pim E. G.
Ponsonby, Anne-Louise
et al.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
EU-Projektnummer
825759
DFG-Projektnummer
Forschungsförderung
Projekt
ENDpoiNTs
Open Access-Veröffentlichung
Sammlungen
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
International Journal of Molecular Sciences (IJMS). Molecular Diversity Preservation International (MDPI). 2020, 21(11), 3978. eISSN 1422-0067. Available under: doi: 10.3390/ijms21113978
Zusammenfassung

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
endocrine-disrupting chemicals; developmental neurotoxicity; chemical testing; adverse outcome pathways
Konferenz
Rezension
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Zitieren
ISO 690LUPU, Diana, Patrik ANDERSSON, Carl-Gustaf BORNEHAG, Barbara DEMENEIX, Ellen FRITSCHE, Chris GENNINGS, Walter LICHTENSTEIGER, Marcel LEIST, Pim E. G. LEONARDS, Anne-Louise PONSONBY, 2020. The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. In: International Journal of Molecular Sciences (IJMS). Molecular Diversity Preservation International (MDPI). 2020, 21(11), 3978. eISSN 1422-0067. Available under: doi: 10.3390/ijms21113978
BibTex
@article{Lupu2020-06-01ENDpo-50593,
  year={2020},
  doi={10.3390/ijms21113978},
  title={The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity},
  number={11},
  volume={21},
  journal={International Journal of Molecular Sciences (IJMS)},
  author={Lupu, Diana and Andersson, Patrik and Bornehag, Carl-Gustaf and Demeneix, Barbara and Fritsche, Ellen and Gennings, Chris and Lichtensteiger, Walter and Leist, Marcel and Leonards, Pim E. G. and Ponsonby, Anne-Louise},
  note={Article Number: 3978}
}
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