KOPS - The Institutional Repository of the University of Konstanz

The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Cite This

Files in this item

Checksum: MD5:fd36b10b1dde08c8db336b68f34d0f89

LUPU, Diana, Patrik ANDERSSON, Carl-Gustaf BORNEHAG, Barbara DEMENEIX, Ellen FRITSCHE, Chris GENNINGS, Walter LICHTENSTEIGER, Marcel LEIST, Pim E. G. LEONARDS, Anne-Louise PONSONBY, 2020. The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. In: International Journal of Molecular Sciences (IJMS). Molecular Diversity Preservation International (MDPI). 21(11), 3978. eISSN 1422-0067. Available under: doi: 10.3390/ijms21113978

@article{Lupu2020-06-01ENDpo-50593, title={The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity}, year={2020}, doi={10.3390/ijms21113978}, number={11}, volume={21}, journal={International Journal of Molecular Sciences (IJMS)}, author={Lupu, Diana and Andersson, Patrik and Bornehag, Carl-Gustaf and Demeneix, Barbara and Fritsche, Ellen and Gennings, Chris and Lichtensteiger, Walter and Leist, Marcel and Leonards, Pim E. G. and Ponsonby, Anne-Louise}, note={Article Number: 3978} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/50593"> <dc:creator>Fritsche, Ellen</dc:creator> <dc:creator>Demeneix, Barbara</dc:creator> <dc:creator>Lichtensteiger, Walter</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Andersson, Patrik</dc:contributor> <dc:contributor>Fritsche, Ellen</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-08-27T11:29:09Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Lupu, Diana</dc:contributor> <dc:creator>Bornehag, Carl-Gustaf</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50593/1/Lupu_2-cab0xux9jd7v5.pdf"/> <dc:contributor>Leist, Marcel</dc:contributor> <dc:creator>Ponsonby, Anne-Louise</dc:creator> <dc:creator>Gennings, Chris</dc:creator> <dc:language>eng</dc:language> <dcterms:title>The ENDpoiNTs Project : Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity</dcterms:title> <dc:contributor>Bornehag, Carl-Gustaf</dc:contributor> <dc:contributor>Lichtensteiger, Walter</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:creator>Leonards, Pim E. G.</dc:creator> <dc:creator>Leist, Marcel</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50593/1/Lupu_2-cab0xux9jd7v5.pdf"/> <dc:creator>Lupu, Diana</dc:creator> <dc:contributor>Gennings, Chris</dc:contributor> <dc:contributor>Ponsonby, Anne-Louise</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-08-27T11:29:09Z</dcterms:available> <dc:contributor>Leonards, Pim E. G.</dc:contributor> <dc:contributor>Demeneix, Barbara</dc:contributor> <dc:creator>Andersson, Patrik</dc:creator> <dcterms:abstract xml:lang="eng">Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.</dcterms:abstract> <dcterms:issued>2020-06-01</dcterms:issued> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/50593"/> <dc:rights>Attribution 4.0 International</dc:rights> </rdf:Description> </rdf:RDF>

Downloads since Aug 27, 2020 (Information about access statistics)

Lupu_2-cab0xux9jd7v5.pdf 150

This item appears in the following Collection(s)

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search KOPS


Browse

My Account