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Medication beliefs in first-line and second-line treated multiple sclerosis patients

Medication beliefs in first-line and second-line treated multiple sclerosis patients

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PUST, Gesa Elena Albertine, Benthe UNTIEDT, Roland WEIERSTALL-PUST, Jennifer RANDERATH, Anna BARABASCH, Anne Christin RAHN, Christoph HEESEN, 2020. Medication beliefs in first-line and second-line treated multiple sclerosis patients. In: Multiple Sclerosis and Related Disorders. Elsevier. 42, 102144. ISSN 2211-0348. eISSN 2211-0356. Available under: doi: 10.1016/j.msard.2020.102144

@article{Pust2020-07Medic-50079, title={Medication beliefs in first-line and second-line treated multiple sclerosis patients}, year={2020}, doi={10.1016/j.msard.2020.102144}, volume={42}, issn={2211-0348}, journal={Multiple Sclerosis and Related Disorders}, author={Pust, Gesa Elena Albertine and Untiedt, Benthe and Weierstall-Pust, Roland and Randerath, Jennifer and Barabasch, Anna and Rahn, Anne Christin and Heesen, Christoph}, note={Article Number: 102144} }

Untiedt, Benthe Pust, Gesa Elena Albertine Weierstall-Pust, Roland Pust, Gesa Elena Albertine Untiedt, Benthe Barabasch, Anna Heesen, Christoph Heesen, Christoph 2020-07-01T09:40:31Z Rahn, Anne Christin Background: Immune treatments of multiple sclerosis (MS) can be classified in first-line and second-line approaches. While in both treatment efficacy is often not easy to assess in the short-term, treatment and illness beliefs may differ in first-line and second-line treated patients. The current study aimed to assess differential beliefs about medicine and illness perception between these groups based on the hypothesis that they are closely connected to adherence behaviour.<br /><br />Methods: An online survey through the website of the German MS Society was performed investigating beliefs about immune treatments as well as the patients’ illness perceptions with validated questionnaires. Demographic factors, disability and self-reported adherence rates were studied as moderator variables.<br /><br />Results: In total, 630 patients participated. Data of 433 first-line treated and 192 second-line treated patients with MS (PwMS) were analysed. Necessity beliefs and also concerns beliefs were significantly higher in second-line treated PwMS (MANCOVA p =.001 and p =.006) and generally in patients with higher disability, while illness perception did not differ between groups. Self-assessed adherence rates were around 70% for oral treatments and injectables irrespective of first-line or second-line. Nonadherence was below 5% for infusion treatments. However, most patients reported only single omissions.<br /><br />Conclusion: The current study reveals differential behavioural attitudes between first-line versus second-line-treated PwMS. However, follow-up studies are needed to further unravel the relationship between behavioural attitudes and treatment adherence. Medication beliefs in first-line and second-line treated multiple sclerosis patients eng Barabasch, Anna Attribution-NonCommercial-NoDerivatives 4.0 International 2020-07 Weierstall-Pust, Roland Rahn, Anne Christin 2020-07-01T09:40:31Z Randerath, Jennifer Randerath, Jennifer

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