Just a very expensive breathing training? : Risk of respiratory artefacts in functional connectivity-based real-time fMRI neurofeedback

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2020
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Weiss, Franziska
Zamoscik, Vera
Halli, Patrick
Kirsch, Peter
Gerchen, Martin Fungisai
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NeuroImage ; 210 (2020). - 116580. - Elsevier. - ISSN 1053-8119. - eISSN 1095-9572
Abstract
Real-time functional magnetic resonance imaging neurofeedback (rtfMRI NFB) is a promising method for targeted regulation of pathological brain processes in mental disorders. But most NFB approaches so far have used relatively restricted regional activation as a target, which might not address the complexity of the underlying network changes. Aiming towards advancing novel treatment tools for disorders like schizophrenia, we developed a large-scale network functional connectivity-based rtfMRI NFB approach targeting dorsolateral prefrontal cortex and anterior cingulate cortex connectivity with the striatum. In a double-blind randomized yoke-controlled single-session feasibility study with N ​= ​38 healthy controls, we identified strong associations between our connectivity estimates and physiological parameters reflecting the rate and regularity of breathing. These undesired artefacts are especially detrimental in rtfMRI NFB, where the same data serves as an online feedback signal and offline analysis target. To evaluate ways to control for the identified respiratory artefacts, we compared model-based physiological nuisance regression and global signal regression (GSR) and found that GSR was the most effective method in our data. Our results strongly emphasize the need to control for physiological artefacts in connectivity-based rtfMRI NFB approaches and suggest that GSR might be a useful method for online data correction for respiratory artefacts.
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Subject (DDC)
150 Psychology
Keywords
Physiological artefacts Frontostriatal functional connectivity fMRI neurofeedback, Large-scale networks, Global signal regression, Schizophrenia, TAPAS, PhysIO toolbox
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Cite This
ISO 690WEISS, Franziska, Vera ZAMOSCIK, Stephanie N. L. SCHMIDT, Patrick HALLI, Peter KIRSCH, Martin Fungisai GERCHEN, 2020. Just a very expensive breathing training? : Risk of respiratory artefacts in functional connectivity-based real-time fMRI neurofeedback. In: NeuroImage. Elsevier. 210, 116580. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2020.116580
BibTex
@article{Weiss2020-04-15expen-49196,
  year={2020},
  doi={10.1016/j.neuroimage.2020.116580},
  title={Just a very expensive breathing training? : Risk of respiratory artefacts in functional connectivity-based real-time fMRI neurofeedback},
  volume={210},
  issn={1053-8119},
  journal={NeuroImage},
  author={Weiss, Franziska and Zamoscik, Vera and Schmidt, Stephanie N. L. and Halli, Patrick and Kirsch, Peter and Gerchen, Martin Fungisai},
  note={Article Number: 116580}
}
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