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Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A

Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A

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MIHAICH, Ellen, Jon RHODES, Jeff WOLF, Nelly VAN DER HOEVEN, Daniel DIETRICH, A. Tilghman HALL, Norbert CASPERS, Lisa ORTEGO, Charles STAPLES, Steve DIMOND, Steven HENTGES, 2012. Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A. In: Environmental Toxicology and Chemistry. Wiley. 31(11), pp. 2525-2535. ISSN 0730-7268. eISSN 1552-8618. Available under: doi: 10.1002/etc.1976

@article{Mihaich2012-11Adult-48555, title={Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A}, year={2012}, doi={10.1002/etc.1976}, number={11}, volume={31}, issn={0730-7268}, journal={Environmental Toxicology and Chemistry}, pages={2525--2535}, author={Mihaich, Ellen and Rhodes, Jon and Wolf, Jeff and van der Hoeven, Nelly and Dietrich, Daniel and Hall, A. Tilghman and Caspers, Norbert and Ortego, Lisa and Staples, Charles and Dimond, Steve and Hentges, Steven} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/48555"> <dc:contributor>Dietrich, Daniel</dc:contributor> <dc:contributor>Caspers, Norbert</dc:contributor> <dc:creator>Mihaich, Ellen</dc:creator> <dc:creator>Dietrich, Daniel</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/48555/1/Mihaich_2-jguuswgf3nkv6.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-02-07T09:34:50Z</dc:date> <dc:creator>Rhodes, Jon</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>van der Hoeven, Nelly</dc:contributor> <dc:creator>Hall, A. Tilghman</dc:creator> <dc:contributor>Staples, Charles</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/48555/1/Mihaich_2-jguuswgf3nkv6.pdf"/> <dc:creator>Dimond, Steve</dc:creator> <dc:creator>van der Hoeven, Nelly</dc:creator> <dc:rights>terms-of-use</dc:rights> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Ortego, Lisa</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:language>eng</dc:language> <dc:creator>Wolf, Jeff</dc:creator> <dc:creator>Staples, Charles</dc:creator> <dc:contributor>Dimond, Steve</dc:contributor> <dc:contributor>Wolf, Jeff</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Hentges, Steven</dc:creator> <dc:creator>Ortego, Lisa</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-02-07T09:34:50Z</dcterms:available> <dc:creator>Caspers, Norbert</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:contributor>Hentges, Steven</dc:contributor> <dc:contributor>Hall, A. Tilghman</dc:contributor> <dcterms:title>Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A</dcterms:title> <dcterms:issued>2012-11</dcterms:issued> <dc:contributor>Rhodes, Jon</dc:contributor> <dc:contributor>Mihaich, Ellen</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/48555"/> <dcterms:abstract xml:lang="eng">Bisphenol A (BPA) is an intermediate used to produce epoxy resins and polycarbonate plastics. Although BPA degrades rapidly in the environment with aquatic half‐lives from 0.5 to 6 d, it can be found in aquatic systems because of widespread use. To evaluate potential effects from chronic exposure, fathead minnows were exposed for 164 d to nominal concentrations of 1, 16, 64, 160, and 640 µg/L BPA. Population‐level endpoints of survival, growth, and reproduction were assessed with supplemental endpoints (e.g., vitellogenin, gonad histology), including gonad cell type assessment and quantification. No statistically significant changes in growth, gonad weight, gonadosomatic index, or reproduction variables (e.g., number of eggs and spawns, hatchability) were observed; however, there was a significant impact on male survival at 640 µg/L. Vitellogenin increased in both sexes at 64 µg/L or higher. Gonad cell type frequencies were significantly different from controls at 160 µg/L or higher in males with a slight decrease in spermatocytes compared with less mature cell types, and at 640 µg/L in females with a slight decrease in early vitellogenic cells compared with less mature cells. The decrease in spermatocytes did not correspond to a decrease in the most mature sex cell type (spermatozoa) and did not impair male fertility, as hatchability was not impacted. Overall, marginal shifts in gametogenic cell maturation were not associated with any statistically significant effects on population‐relevant reproductive endpoints (growth, fecundity, and hatchability) at any concentration tested.</dcterms:abstract> </rdf:Description> </rdf:RDF>

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