Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

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2019
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Giacconi, Robertina
Malavolta, Marco
Franceschi, Claudio
Capri, Miriam
Slagboom, P. Eline
Jansen, Eugène H. J. M.
Dollé, Martijn E. T.
Provinciali, Mauro
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Nutrients. 2019, 11(12), 2986. eISSN 2072-6643. Available under: doi: 10.3390/nu11122986
Zusammenfassung

Alu hypomethylation promotes genomic instability and is associated with aging and age-related diseases. Dietary factors affect global DNA methylation, leading to changes in genomic stability and gene expression with an impact on longevity and the risk of disease. This preliminary study aims to investigate the relationship between nutritional factors, such as circulating trace elements, lipids and antioxidants, and Alu methylation in elderly subjects and offspring of healthy nonagenarians. Alu DNA methylation was analyzed in sixty RASIG (randomly recruited age-stratified individuals from the general population) and thirty-two GO (GeHA offspring) enrolled in Italy in the framework of the MARK-AGE project. Factor analysis revealed a different clustering between Alu CpG1 and the other CpG sites. RASIG over 65 years showed lower Alu CpG1 methylation than those of GO subjects in the same age class. Moreover, Alu CpG1 methylation was associated with fruit and whole-grain bread consumption, LDL2-Cholesterol and plasma copper. The preserved Alu methylation status in GO, suggests Alu epigenetic changes as a potential marker of aging. Our preliminary investigation shows that Alu methylation may be affected by food rich in fibers and antioxidants, or circulating LDL subfractions and plasma copper.

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Alu methylation; aging; longevity; nutrients; antioxidant
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ISO 690GIACCONI, Robertina, Marco MALAVOLTA, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Claudio FRANCESCHI, Miriam CAPRI, P. Eline SLAGBOOM, Eugène H. J. M. JANSEN, Martijn E. T. DOLLÉ, Mauro PROVINCIALI, 2019. Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians. In: Nutrients. 2019, 11(12), 2986. eISSN 2072-6643. Available under: doi: 10.3390/nu11122986
BibTex
@article{Giacconi2019-12-06Nutri-48133,
  year={2019},
  doi={10.3390/nu11122986},
  title={Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians},
  number={12},
  volume={11},
  journal={Nutrients},
  author={Giacconi, Robertina and Malavolta, Marco and Bürkle, Alexander and Moreno-Villanueva, Maria and Franceschi, Claudio and Capri, Miriam and Slagboom, P. Eline and Jansen, Eugène H. J. M. and Dollé, Martijn E. T. and Provinciali, Mauro},
  note={Article Number: 2986}
}
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