Schnelle und aussagekräftige Genotoxizitätsbewertung

Type of Publication: Journal article
Publication status: Published
Author: Moreno-Villanueva, Maria; Pilartz, Marcel; Unger, Miriam
Year of publication: 2013
Published in: BIOspektrum ; 19 (2013), 5. - pp. 536-538. - ISSN 0947-0867. - eISSN 1868-6249
DOI (citable link): https://dx.doi.org/10.1007/s12268-013-0352-7
Summary:
At present, just a few of the available in vitro genotoxicity tests measure DNA strand breaks and their repair in cells. The comet assay as the considered “gold standard” is still not standardized and does not allow full automation so far. In contrast, most steps of the fluorimetic analysis of alkaline DNA unwinding (FADU) assay could be automated which allows precise dispensing of solutions and control of temperature and process time during the assay. This progress has led to improved reproducibility and throughput, easier handling, and enhanced sensitivity and speed.
Subject (DDC): 796 Sport
Bibliography of Konstanz: Yes
Refereed: Yes

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MORENO-VILLANUEVA, Maria, Marcel PILARTZ, Miriam UNGER, 2013. Schnelle und aussagekräftige Genotoxizitätsbewertung. In: BIOspektrum. 19(5), pp. 536-538. ISSN 0947-0867. eISSN 1868-6249. Available under: doi: 10.1007/s12268-013-0352-7

@article{MorenoVillanueva2013-09Schne-47423, title={Schnelle und aussagekräftige Genotoxizitätsbewertung}, year={2013}, doi={10.1007/s12268-013-0352-7}, number={5}, volume={19}, issn={0947-0867}, journal={BIOspektrum}, pages={536--538}, author={Moreno-Villanueva, Maria and Pilartz, Marcel and Unger, Miriam} }

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