Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können am Montag, 6.2. und Dienstag, 7.2. keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted on Monday, Feb. 6 and Tuesday, Feb. 7.)
Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-x7pip6fpd4cl9 |
Author: | Peck, Spencer C.; Denger, Karin; Burrichter, Anna; Irwin, Stephania M.; Balskus, Emily P.; Schleheck, David |
Year of publication: | 2019 |
Published in: | Proceedings of the National Academy of Sciences of the United States of America (PNAS) ; 116 (2019), 8. - pp. 3171-3176. - ISSN 0027-8424. - eISSN 1091-6490 |
Pubmed ID: | 30718429 |
DOI (citable link): | https://dx.doi.org/10.1073/pnas.1815661116 |
Summary: |
This paper describes a pathway for anaerobic bacterial metabolism of taurine (2-aminoethanesulfonate), an abundant substrate in the human intestinal microbiota, by the intestinal bacterium and opportunistic pathogen, Bilophila wadsworthia. This metabolism converts taurine to the toxic metabolite hydrogen sulfide (H2S), an activity associated with inflammatory bowel disease and colorectal cancer. A critical enzyme in this pathway is isethionate sulfite-lyase, a member of the glycyl radical enzyme family. This enzyme catalyzes a novel, radical-based C-S bond-cleavage reaction to convert isethionate (2-hydroxyethanesulfonate) to sulfite and acetaldehyde. This discovery improves our understanding of H2S production in the human body and may also offer new approaches for controlling intestinal H2S production and B. wadsworthia infections.
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Subject (DDC): | 570 Biosciences, Biology |
Link to License: | Attribution 4.0 International |
Bibliography of Konstanz: | Yes |
Refereed: | Yes |
PECK, Spencer C., Karin DENGER, Anna BURRICHTER, Stephania M. IRWIN, Emily P. BALSKUS, David SCHLEHECK, 2019. A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. In: Proceedings of the National Academy of Sciences of the United States of America (PNAS). 116(8), pp. 3171-3176. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1815661116
@article{Peck2019-02-19glycy-46846, title={A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia}, year={2019}, doi={10.1073/pnas.1815661116}, number={8}, volume={116}, issn={0027-8424}, journal={Proceedings of the National Academy of Sciences of the United States of America (PNAS)}, pages={3171--3176}, author={Peck, Spencer C. and Denger, Karin and Burrichter, Anna and Irwin, Stephania M. and Balskus, Emily P. and Schleheck, David} }
Peck_2-x7pip6fpd4cl9.pdf | 305 |