@article{Peck2019-02-19glycy-46846,
  year={2019},
  doi={10.1073/pnas.1815661116},
  title={A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia},
  number={8},
  volume={116},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences of the United States of America (PNAS)},
  pages={3171--3176},
  author={Peck, Spencer C. and Denger, Karin and Burrichter, Anna Georga and Irwin, Stephania M. and Balskus, Emily P. and Schleheck, David}
}

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    <dc:contributor>Peck, Spencer C.</dc:contributor>
    <dcterms:issued>2019-02-19</dcterms:issued>
    <dc:contributor>Denger, Karin</dc:contributor>
    <dcterms:title>A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia</dcterms:title>
    <dcterms:abstract xml:lang="eng">This paper describes a pathway for anaerobic bacterial metabolism of taurine (2-aminoethanesulfonate), an abundant substrate in the human intestinal microbiota, by the intestinal bacterium and opportunistic pathogen, Bilophila wadsworthia. This metabolism converts taurine to the toxic metabolite hydrogen sulfide (H&lt;sub&gt;2&lt;/sub&gt;S), an activity associated with inflammatory bowel disease and colorectal cancer. A critical enzyme in this pathway is isethionate sulfite-lyase, a member of the glycyl radical enzyme family. This enzyme catalyzes a novel, radical-based C-S bond-cleavage reaction to convert isethionate (2-hydroxyethanesulfonate) to sulfite and acetaldehyde. This discovery improves our understanding of H&lt;sub&gt;2&lt;/sub&gt;S production in the human body and may also offer new approaches for controlling intestinal H&lt;sub&gt;2&lt;/sub&gt;S production and B. wadsworthia infections.</dcterms:abstract>
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    <dc:contributor>Schleheck, David</dc:contributor>
    <dc:contributor>Burrichter, Anna Georga</dc:contributor>
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    <dc:creator>Irwin, Stephania M.</dc:creator>
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    <dc:contributor>Irwin, Stephania M.</dc:contributor>
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    <dc:creator>Denger, Karin</dc:creator>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-09-12T13:28:34Z</dc:date>
    <dc:creator>Peck, Spencer C.</dc:creator>
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    <dc:contributor>Balskus, Emily P.</dc:contributor>
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