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The Trier Social Stress Test in first episode psychosis patients : Impact of perceived stress, protective factors and childhood trauma

The Trier Social Stress Test in first episode psychosis patients : Impact of perceived stress, protective factors and childhood trauma

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SEITZ, Raffaela, Nadia VRACOTAS, Laura BECHARD-EVANS, Suzanne KING, Sherezad ABADI, Ridha JOOBER, Jai L. SHAH, Ashok K. MALLA, Marita PRUESSNER, 2019. The Trier Social Stress Test in first episode psychosis patients : Impact of perceived stress, protective factors and childhood trauma. In: Psychoneuroendocrinology. 105, pp. 155-163. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2019.01.010

@article{Seitz2019-07Trier-46440, title={The Trier Social Stress Test in first episode psychosis patients : Impact of perceived stress, protective factors and childhood trauma}, year={2019}, doi={10.1016/j.psyneuen.2019.01.010}, volume={105}, issn={0306-4530}, journal={Psychoneuroendocrinology}, pages={155--163}, author={Seitz, Raffaela and Vracotas, Nadia and Bechard-Evans, Laura and King, Suzanne and Abadi, Sherezad and Joober, Ridha and Shah, Jai L. and Malla, Ashok K. and Pruessner, Marita} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/46440"> <dc:contributor>Pruessner, Marita</dc:contributor> <dc:creator>Malla, Ashok K.</dc:creator> <dc:creator>Joober, Ridha</dc:creator> <dcterms:abstract xml:lang="eng">Psychosis has been associated with abnormalities in hypothalamic-pituitary-adrenal axis functioning, which may emerge through heightened stress sensitivity following early life adversity - ultimately resulting in illness onset and progression. The present study assessed cortisol levels during an established psychosocial stress task and their association with current stress perception, putative protective factors and adverse childhood experiences in patients with a first episode of psychosis (FEP). A total of 100 volunteers participated in the study, 57 of whom were patients with a FEP (mean age 23.9 ± 3.8) and 43 healthy community controls (mean age 23.2 ± 3.9). Salivary cortisol, heart rate and blood pressure were measured at eight time points before and after the Trier Social Stress Test. Subjective stress and protective factors were assessed with the Perceived Stress Scale, the Self-Esteem Rating Scale and the Brief COPE. Early life adversity was assessed with the Childhood Trauma Questionnaire. Patients compared to controls showed significantly lower cortisol levels (F = 7.38; p = .008) throughout the afternoon testing period, but no difference in the cortisol response to the TSST. Heart rate was elevated and protective factors were lower in patients compared to controls. Attenuated cortisol levels were associated with higher levels of perceived stress, poor protective factors and more physical neglect during childhood. Our results suggest that attenuated baseline cortisol levels and not a blunted response during an acute stress task might be an indicator of heightened stress vulnerability and poor resilience in psychosis. The possible influence of childhood adversity and antipsychotic medication is discussed.</dcterms:abstract> <dc:creator>Pruessner, Marita</dc:creator> <dc:contributor>Bechard-Evans, Laura</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>King, Suzanne</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46440"/> <dc:language>eng</dc:language> <dc:creator>Seitz, Raffaela</dc:creator> <dc:creator>King, Suzanne</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Abadi, Sherezad</dc:contributor> <dcterms:issued>2019-07</dcterms:issued> <dcterms:title>The Trier Social Stress Test in first episode psychosis patients : Impact of perceived stress, protective factors and childhood trauma</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-17T14:17:39Z</dc:date> <dc:creator>Bechard-Evans, Laura</dc:creator> <dc:contributor>Malla, Ashok K.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-17T14:17:39Z</dcterms:available> <dc:creator>Abadi, Sherezad</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:creator>Vracotas, Nadia</dc:creator> <dc:contributor>Seitz, Raffaela</dc:contributor> <dc:contributor>Vracotas, Nadia</dc:contributor> <dc:contributor>Joober, Ridha</dc:contributor> <dc:contributor>Shah, Jai L.</dc:contributor> <dc:creator>Shah, Jai L.</dc:creator> </rdf:Description> </rdf:RDF>

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