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The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a)

The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a)

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Prüfsumme: MD5:4b6e7e288edc638bb8c23c249d9e19b7

PELZ, Daniela, Tina ROESKE, Zainulabeuddin SYED, Marien de BRUYNE, Giovanni GALIZIA, 2006. The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a). In: Journal of Neurobiology. 66(14), pp. 1544-1563. ISSN 0022-3034. Available under: doi: 10.1002/neu.20333

@article{Pelz2006-12molec-457, title={The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a)}, year={2006}, doi={10.1002/neu.20333}, number={14}, volume={66}, issn={0022-3034}, journal={Journal of Neurobiology}, pages={1544--1563}, author={Pelz, Daniela and Roeske, Tina and Syed, Zainulabeuddin and Bruyne, Marien de and Galizia, Giovanni} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/457"> <dc:creator>Galizia, Giovanni</dc:creator> <dcterms:issued>2006-12</dcterms:issued> <dcterms:bibliographicCitation>First publ. in: Journal of Neurobiology 66 (2006), 14, pp. 1544 1563</dcterms:bibliographicCitation> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-20T14:25:45Z</dc:date> <dc:contributor>Pelz, Daniela</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-20T14:25:45Z</dcterms:available> <dcterms:title>The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a)</dcterms:title> <dc:creator>Pelz, Daniela</dc:creator> <dc:contributor>Roeske, Tina</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Galizia, Giovanni</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Roeske, Tina</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/457"/> <dcterms:abstract xml:lang="eng">Understanding how odors are coded within an olfactory system requires knowledge about its input. This is constituted by the molecular receptive ranges (MRR) of olfactory sensory neurons that converge in the glomeruli of the olfactory bulb (vertebrates) or the antennal lobe (AL, insects). Aiming at a comprehensive characterization of MRRs in Drosophila melanogaster we measured odor-evoked calcium responses in olfactory sensory neurons that express the olfactory receptor Or22a. We used an automated stimulus application system to screen [Ca2+] responses to 104 odors both in the antenna (sensory transduction) and in the AL (neuronal transmission). At 10−2 (vol/vol) dilution, 39 odors elicited at least a half-maximal response. For these odorants we established dose-response relationships over their entire dynamic range. We tested 15 additional chemicals that are structurally related to the most efficient odors. Ethyl hexanoate and methyl hexanoate were the best stimuli, eliciting consistent responses at dilutions as low as 10−9. Two substances led to calcium decrease, suggesting that Or22a might be constitutively active, and that these substances might act as inverse agonists, reminiscent of G-protein coupled receptors. There was no difference between the antennal and the AL MRR. Furthermore we show that Or22a has a broad yet selective MRR, and must be functionally described both as a specialist and a generalist. Both these descriptions are ecologically relevant. Given that adult Drosophila use approximately 43 ORs, a complete description of all MRRs appears now in reach.</dcterms:abstract> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/457/1/galizia.pdf"/> <dc:creator>Bruyne, Marien de</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Syed, Zainulabeuddin</dc:contributor> <dc:creator>Syed, Zainulabeuddin</dc:creator> <dc:format>application/pdf</dc:format> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Bruyne, Marien de</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/457/1/galizia.pdf"/> </rdf:Description> </rdf:RDF>

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