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Gender differences in childhood trauma in first episode psychosis : Association with symptom severity over two years

Gender differences in childhood trauma in first episode psychosis : Association with symptom severity over two years

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PRUESSNER, Marita, Suzanne KING, Nadia VRACOTAS, Sherezad ABADI, Srividya IYER, Ashok K. MALLA, Jai SHAH, Ridha JOOBER, 2019. Gender differences in childhood trauma in first episode psychosis : Association with symptom severity over two years. In: Schizophrenia Research. 205, pp. 30-37. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2018.06.043

@article{Pruessner2019-03Gende-45589, title={Gender differences in childhood trauma in first episode psychosis : Association with symptom severity over two years}, year={2019}, doi={10.1016/j.schres.2018.06.043}, volume={205}, issn={0920-9964}, journal={Schizophrenia Research}, pages={30--37}, author={Pruessner, Marita and King, Suzanne and Vracotas, Nadia and Abadi, Sherezad and Iyer, Srividya and Malla, Ashok K. and Shah, Jai and Joober, Ridha} }

Shah, Jai Pruessner, Marita Malla, Ashok K. King, Suzanne Gender differences in childhood trauma in first episode psychosis : Association with symptom severity over two years 2019-04-05T09:28:56Z Vracotas, Nadia King, Suzanne Joober, Ridha Shah, Jai eng 2019-03 Vracotas, Nadia 2019-04-05T09:28:56Z Pruessner, Marita Iyer, Srividya Early life adversity is associated with increased risk for psychosis onset and poor clinical outcome. Male compared to female patients often show a more severe course of psychotic illness. The aim of the present study was to investigate gender differences in childhood trauma (CT) and their impact on symptomatic and functional outcome following psychosis onset.<br /><br />The study included 210 patients (144 men, 66 women) diagnosed with a first-episode of psychosis (FEP). Early adversity was assessed with the Childhood Trauma Questionnaire. Psychotic symptoms and general functioning were rated with the Brief Psychiatric Rating Scale and Global Assessment of Functioning scale at baseline, 12 and 24 months of follow-up in an established early intervention service.<br /><br />Male patients reported higher rates of physical or emotional neglect, whereas female patients indicated significantly higher rates of emotional abuse. More severe CT was related to higher levels of depression in women and to negative symptoms in men. Distinct CT effects were observed on positive and negative symptom severity and global functioning in male patients at 24 months. Emotional abuse was the strongest predictor of depression in both genders. In male patients only, emotional abuse predicted positive symptom severity and impaired global functioning, whereas emotional neglect predicted more severe negative symptoms.<br /><br />Our results suggest differences in CT experiences in male and female FEP patients, with a more pronounced impact on longer-term outcome in male patients. The findings support the notion that sex differences in stress vulnerability account for the relatively poor illness course in male psychosis patients. Malla, Ashok K. Abadi, Sherezad Iyer, Srividya Abadi, Sherezad Joober, Ridha

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