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Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls

Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls

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BUMB, Jan Malte, Daniela MIER, Ingo NOELTE, Michael SCHREDL, Peter KIRSCH, Oliver HENNIG, Luisa LIEBRICH, Sabrina FENSKE, Barbara ALM, Carina SAUER, 2016. Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls. In: European Neuropsychopharmacology. 26(7), pp. 1119-1126. ISSN 0924-977X. eISSN 1873-7862. Available under: doi: 10.1016/j.euroneuro.2016.03.016

@article{Bumb2016Assoc-45245, title={Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls}, year={2016}, doi={10.1016/j.euroneuro.2016.03.016}, number={7}, volume={26}, issn={0924-977X}, journal={European Neuropsychopharmacology}, pages={1119--1126}, author={Bumb, Jan Malte and Mier, Daniela and Noelte, Ingo and Schredl, Michael and Kirsch, Peter and Hennig, Oliver and Liebrich, Luisa and Fenske, Sabrina and Alm, Barbara and Sauer, Carina} }

Schredl, Michael Alm, Barbara Sauer, Carina Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls Hennig, Oliver terms-of-use 2019-02-28T08:09:02Z Bumb, Jan Malte Fenske, Sabrina Hennig, Oliver Sauer, Carina Liebrich, Luisa eng Alm, Barbara Mier, Daniela Bumb, Jan Malte Noelte, Ingo The pineal gland, as part of the human epithalamus, is the main production site of peripheral melatonin, which promotes the modulation of sleep patterns, circadian rhythms and circadian preferences (morningness vs. eveningness). The present study analyses the pineal gland volume (PGV) and its association with circadian preferences and symptom severity in adult ADHD patients compared to healthy controls. PGV was determined manually using high-resolution 3T MRI (T1-magnetization prepared rapid gradient echo) in medication free adult ADHD patients (N=74) compared to healthy controls (N=86). Moreover, the Morningness-Eveningness Questionnaire (MEQ), the ADHD Diagnostic Checklist and the Wender-Utah Rating Scale were conducted. PGV differed between both groups (patients: 59.9±33.8mm(3); healthy controls: 71.4±27.2mm(3), P=0.04). In ADHD patients, more eveningness types were revealed (patients: 29%; healthy controls: 17%; P=0.05) and sum scores of the MEQ were lower (patients: 45.8±11.5; healthy controls 67.2±10.1; P<0.001). Multiple regression analyses indicated a positive correlation of PGV and MEQ scores in ADHD (β=0.856, P=0.003) but not in healthy controls (β=0.054, P=0.688). Patients' MEQ scores (β=-0.473, P=0.003) were negatively correlated to ADHD symptoms. The present results suggest a linkage between the PGV and circadian preference in adults with ADHD and an association of the circadian preference to symptom severity. This may facilitate the development of new chronobiological treatment approaches for the add-on treatment in ADHD. Kirsch, Peter Noelte, Ingo Fenske, Sabrina 2016 Kirsch, Peter Schredl, Michael Liebrich, Luisa Mier, Daniela 2019-02-28T08:09:02Z

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