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Neural correlates of effort-dependent and effort-independent cognitive fatigue components in patients with multiple sclerosis

Neural correlates of effort-dependent and effort-independent cognitive fatigue components in patients with multiple sclerosis

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SPITERI, Stefan, Thomas HASSA, Dolores CLAROS-SALINAS, Christian DETTMERS, Mircea Ariel SCHOENFELD, 2019. Neural correlates of effort-dependent and effort-independent cognitive fatigue components in patients with multiple sclerosis. In: Multiple Sclerosis Journal. 25(2), pp. 256-266. ISSN 1352-4585. eISSN 1477-0970. Available under: doi: 10.1177/1352458517743090

@article{Spiteri2019Neura-45206, title={Neural correlates of effort-dependent and effort-independent cognitive fatigue components in patients with multiple sclerosis}, year={2019}, doi={10.1177/1352458517743090}, number={2}, volume={25}, issn={1352-4585}, journal={Multiple Sclerosis Journal}, pages={256--266}, author={Spiteri, Stefan and Hassa, Thomas and Claros-Salinas, Dolores and Dettmers, Christian and Schoenfeld, Mircea Ariel} }

Dettmers, Christian Claros-Salinas, Dolores Background:<br />Among patients with multiple sclerosis (MS), fatigue is the most commonly reported symptom. It can be subdivided into an effort-dependent (fatigability) and an effort-independent component (trait-fatigue).<br /><br />Objective:<br />The objective was to disentangle activity changes associated with effort-independent “trait-fatigue” from those associated with effort-dependent fatigability in MS patients.<br /><br />Methods:<br />This study employed behavioral measures and functional magnetic imaging to investigate neural changes in MS patients associated with fatigue. A total of 40 MS patients and 22 age-matched healthy controls performed in a fatigue-inducing N-back task. Effort-independent fatigue was assessed using the Fatigue Scale of Motor and Cognition (FSMC) questionnaire.<br /><br />Results:<br />Effort-independent fatigue was observed to be reflected by activity increases in fronto-striatal-subcortical networks primarily involved in the maintenance of homeostatic processes and in motor and cognitive control. Effort-dependent fatigue (fatigability) leads to activity decreases in attention-related cortical and subcortical networks.<br /><br />Conclusion:<br />These results indicate that effort-independent (fatigue) and effort-dependent fatigue (fatigability) in MS patients have functionally related but fundamentally different neural correlates. Fatigue in MS as a general phenomenon is reflected by complex interactions of activity increases in control networks (effort-independent component) and activity reductions in executive networks (effort-dependent component) of brain areas. Spiteri, Stefan Hassa, Thomas Schoenfeld, Mircea Ariel terms-of-use eng 2019-02-25T13:17:58Z Dettmers, Christian Neural correlates of effort-dependent and effort-independent cognitive fatigue components in patients with multiple sclerosis Schoenfeld, Mircea Ariel Spiteri, Stefan 2019-02-25T13:17:58Z Hassa, Thomas Claros-Salinas, Dolores 2019

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