KOPS - The Institutional Repository of the University of Konstanz

Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients

Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

AHMED, Asma, Juliane SCHWADERER, Annika HANTUSCH, Kaija-Leena KOLHO, Thomas BRUNNER, 2019. Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients. In: Genes and Immunity. ISSN 1466-4879. eISSN 1476-5470. Available under: doi: 10.1038/s41435-019-0056-1

@article{Ahmed2019-01-28Intes-45043, title={Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients}, year={2019}, doi={10.1038/s41435-019-0056-1}, issn={1466-4879}, journal={Genes and Immunity}, author={Ahmed, Asma and Schwaderer, Juliane and Hantusch, Annika and Kolho, Kaija-Leena and Brunner, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/45043"> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-14T14:13:48Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:creator>Ahmed, Asma</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/45043"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">Inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis are devastating chronic immunopathologies of the intestinal mucosa, which are frequently treated by immunosuppressive glucocorticoids. Endogenous glucocorticoids are not only produced by the adrenal glands, but also by the intestinal epithelium. Local glucocorticoid synthesis critically contributes to the immune homeostasis of the intestinal mucosa. As defective intestinal glucocorticoid synthesis has been associated with the development of IBD, we investigated the expression of steroidogenic enzymes and the key transcriptional regulator Liver Receptor Homolog-1 (LRH-1/NR5A2) in ileal and colonic biopsies human pediatric IBD and control patients. Furthermore, the induction of steroidogenic enzymes and their transcriptional regulation by LRH-1 was investigated in a mouse model of experimental colitis. These analyses revealed that colitis-induced expression of steroidogenic enzymes in the murine colon is dependent on the presence of LRH-1, as intestinal deletion of LRH-1 strongly reduced their colitis-induced expression. Similarly, a strong correlation between the expression of LRH-1 and different steroidogenic enzymes was seen in intestinal biopsies of human pediatric patients. Importantly, reduced expression of hydroxysteroid dehydrogenase 11B1 (HSD11B1) was observed in IBD patients compared to control patients, suggesting that defective local reactivation of glucocorticoids could contribute to the pathogenesis of IBD.</dcterms:abstract> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:contributor>Kolho, Kaija-Leena</dc:contributor> <dcterms:title>Intestinal glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease patients</dcterms:title> <dc:contributor>Ahmed, Asma</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Brunner, Thomas</dc:creator> <dc:contributor>Schwaderer, Juliane</dc:contributor> <dc:creator>Schwaderer, Juliane</dc:creator> <dc:contributor>Hantusch, Annika</dc:contributor> <dc:creator>Kolho, Kaija-Leena</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-14T14:13:48Z</dcterms:available> <dc:creator>Hantusch, Annika</dc:creator> <dcterms:issued>2019-01-28</dcterms:issued> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account